IMMUNIZATION OF MACAQUES WITH SINGLE-CYCLE SIV AS NOVEL AIDS VACCINE APPROACH

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 用三种不同的单周期SIV株免疫恒河猴，这些SIV株表达的包膜糖蛋白被修改为缺乏干扰中和抗体产生的结构特征，以确定增强包膜特异性抗体反应是否可以改善这种疫苗方法提供的保护程度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Rhesus macaques were immunized with three different strains of single-cycle SIV that express envelope glycoproteins modified to lack structural features that interfere with the development of neutralizing antibodies to determine if enhancing envelope-specific antibody responses might improve the extent of protection afforded by this vaccine approach.