PROTECTIVE MECHANISMS WITH ATTENUATED LENTIVIRAL VACCINES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 艾滋病毒是一种性传播疾病，能够预防艾滋病毒性传播的疫苗应该能在生殖道引起粘膜免疫反应。这项研究的目的是确定哪些免疫反应提供了对SIVmac 239阴道内攻击的保护。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. HIV is a sexually transmitted disease and a vaccine capable of preventing sexual transmission of HIV should elicit mucosal immune responses in the genital tract. The objectives of this study were to determine which immune responses confer protection from intravaginal challenge with SIVmac 239.