VACCINE AGAINST CHLAMYDIAL GENITAL TRACT DISEASE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 沙眼衣原体是世界上最流行的性传播细菌感染(STI)。在女性中，生殖器感染可导致子宫内膜炎和盆腔炎(PID)，从而增加异位妊娠或不孕的风险。尽管抗生素治疗可以消除感染，但它并不能改善既定的病理。目前还没有预防感染或限制后遗症的疫苗。迫切需要一种新的方法来刺激细胞对这种细胞内病原体的免疫反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Chlamydia trachomatis is the most prevalent sexually transmitted bacterial infection (STI) in the world. In women, genital infection can result in endometritis and pelvic inflammatory disease (PID) leading to elevated risk of ectopic pregnancy or infertility. Although antibiotic therapy eliminates infection, it does not ameliorate established pathology. A vaccine that prevents infection or limits sequelae is not available. A new approach that stimulates cell mediated immune responses to this intracellular pathogen is urgently required.