IMMUNE ACTIVATION IN AFRICAN GREEN MONKEYS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 猴免疫缺陷病毒(SIV)是一种在包括非洲绿猴(AGM)在内的多种非洲非人灵长类动物中自然发生的感染，通常导致临床上不明显的感染。在SIV自然宿主和非自然宿主之间观察到的艾滋病病毒感染的主要区别之一是没有慢性免疫激活。在这里，我们研究了反复给予细胞因子对AGM慢性SIVagm感染的免疫激活的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Simian immunodeficiency virus (SIV) is a naturally occurring infection in a wide range of African nonhuman primates, including African green monkeys (AGM), which generally results in a clinically unapparent infection. One of the major differences observed in AIDS virus infection between natural hosts of SIV and nonnatural hosts of AIDS viruses is the absence of chronic immune activation. Here we have investigated the effect experimental immune activation by repeated cytokine administrations on chronic SIVagm infection in AGM.