PATHOGENESIS OF ORAL RHESUS LYMPHOCRYPTOVIRUS INFECTION

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 口腔恒河猴淋巴病毒感染的发病机制 这项研究的总体目标是了解裂解病毒复制在免疫活性和免疫抑制宿主的急性EBV感染中的作用。该建议包括以下具体目标： 具体目标#1-口服免疫能力强的恒河猴后，病毒复制在原发重组人LCV感染中的作用是什么？ 特定目标#2-口服接种免疫抑制的SIV恒河猴后，病毒复制在原发重组人LCV感染中的作用是什么？ 特定目标#3--在急性重组人LCV感染中，CD8+CTL对溶解蛋白的特异性形成有多早？ 这些研究将阐明溶血性病毒复制和免疫反应在急性感染中的作用 否则，在人类身上研究将是困难的，或者是不可能的。更好地理解Lytic之间的相互作用 EBV感染和对EBV裂解蛋白的免疫应答将有助于开发新的治疗方法 控制EBV感染和与EBV裂解复制相关的疾病的方法，如口腔毛发 黏膜白斑。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Pathogenesis of oral rhesus lymphocryptovirus infection The overall goal of this study is understand the role of lytic viral replication during acute EBV infection of immunocompetent and immunosuppressed hosts. The proposal includes the following specific aims: Specific Aim #1 - What is the role of viral replication in primary rhLCV infection after oral inoculation of immunocompetent rhesus macaques? Specific Aim #2 - What is the role of viral replication in primary rhLCV infection after oral inoculation of SHIV immunosuppressed rhesus macaques? Specific aim #3 - How early do CD8+ CTL specific for lytic proteins develop in acute rhLCV infection? These studies will elucidate the role of lytic viral replication and the immune response during acute infection that would otherwise be difficult, or impossible, to study in humans. A better understanding of the interplay between lytic EBV infection and the immune response to lytic EBV proteins will contribute to development of novel therapeutic approaches for control of EBV infection and diseases associated with lytic EBV replication, such as oral hairy leukoplakia.