SEX DIFFERENCES IN THE ABUSE-RELATED EFFECTS OF BENZODIAZEPINES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 安定和相关药物，被称为“苯二氮卓类”，被广泛用于治疗焦虑和睡眠障碍，这是美国最常见的两种精神疾病。苯二氮卓类被认为是现代医学中最安全的处方药之一，但不幸的是，它们也是滥用药物，女性的患病率高于男性。 本次修订的目的是揭示苯二氮卓类药物滥用潜力的性别差异，总体目标是开发更安全的药物来治疗焦虑和睡眠障碍，无论性别如何。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Valium and related drugs, referred to as "benzodiazepines" are prescribed widely for the treatment of anxiety and sleep disorders, two of the most common psychiatric disorders in the U.S. Benzodiazepines are considered to be among the safest prescription drugs in modern medicine, but they unfortunately are also drugs of abuse, with higher prevalence in women than men. The aim of this revision to our parent grant is to uncover sex differences in the abuse potential of benzodiazepines, with the overall goal of developing safer drugs for treating anxiety and sleep disorders regardless of gender.