TAAR1 POLYMORPHISMS IN RHESUS MONKEYS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 TAAR1受体在调节大脑单胺系统中日益显现的重要性，为确定该基因的多态变异是否具有功能以及研究人类和恒河猴以及其他物种之间的显著相似性提供了强有力的理论基础。我们应用实验室在评估TAAR1功能方面的重要专业知识，在与药物成瘾和神经精神障碍相关的恒河猴基因中发现的多态性，以及遗传变异功能评估来研究TAAR1基因座。我们在恒河猴和人类TAAR1中都发现了新的遗传多态，并发现在不同物种中，只有犬形食肉动物有缺失的基因。基因家族在某些哺乳动物中扩大了，特别是啮齿类动物，而在其他动物中，包括灵长类动物，则减少了。通过将示踪胺相关受体放在进化的背景下，我们可以更好地了解它们的功能以及它们与行为和神经疾病的潜在关联。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The emerging importance of the TAAR1 receptor in modulating brain monoamine systems provides a strong rationale for determining whether polymorphic variation at the locus is functional and examining the significant similarities between human and rhesus monkeys, as well as other species. We have applied our laboratory's significant expertise in assessing TAAR1 function, polymorphism discovery in rhesus monkey genes associated with drug addiction and neuropsychiatric disorders, and genetic variant functional assessments to investigate of the TAAR1 locus. We identified novel genetic polymorphisms in both the rhesus monkey and human TAAR1, and have found that across species, only the caniform carnivores have a deleted gene. The gene family has seen expansions among certain mammals, notably rodents, and reductions in others, including primates. By placing the trace amine associated receptors in an evolutionary context we can better understand their function and their potential associations with behavior and neurological disease.