EPIGENETIC REGULATION OF SEROTONIN: RELEVANCE TO HIV AND METHAMPHETAMINE ABUSE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 了解艾滋病毒、甲基苯丙胺滥用和5-羟色胺系统变化之间的联系，对于为艾滋病和甲基苯丙胺成瘾制定新的预防和治疗战略至关重要，这两种疾病的并发症很高。该项目调查了5-羟色胺神经传递的表观遗传调节及其与艾滋病毒和甲基苯丙胺滥用的相关性。我们预计，从这个项目产生的研究结果将提供新的见解的5-羟色胺系统的调节，并将导致新的战略，以治疗艾滋病毒感染和甲基苯丙胺成瘾及其合并症。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Understanding the link between HIV, methamphetamine abuse and changes in the serotonin system is critical to designing new preventative and therapeutic strategies for both AIDS and methamphetamine addiction, which have high co-morbidity. This project investigates the epigenetic regulation of serotonin neurotransmission and its relevance to HIV and methamphetamine abuse. We anticipate that the research findings generated from this project will provide new insights into the regulation of the serotonin system and will lead to new strategies to treat HIV-infection and methamphetamine addiction and their co-morbidity.