NOVEL IONOPHORIC MACROMOLECULES AND POTENTIAL FUNGICIDES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这项工作将涉及生产新的生物活性分子，特别是我们将集中在设计具有抗微生物和抗真菌特性的化合物。这项有机合成研究将集中在1，3偶极环加成反应中，以丁腈氧化物或亚硝酸硅酸盐为中间体，合成杂环化合物。拟议的抗微生物项目将涉及将这些较小的单元连接在一起以形成一个可以作为离子载体发挥作用的大循环的挑战。抗真菌项目将涉及对一类新化合物的合成进行调查。预计这些潜在的聚酯大分子和异恶唑杀菌剂中的一些变量将非常容易改变。例如，可以通过改变四氢呋喃环上3，4-取代基的对称性来考察大环的对称性。大环化的官能度可以从聚酯到聚醚再到聚酰胺。因此，有许多变量可以被利用来产生一系列具有良好的金属阳离子结合的大环。对于许多对生物医学研究背后的化学和生物学感兴趣的学生来说，这个研究项目将是一个极好的机会。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This work would involve the production of novel biologically active molecules, in particular we would center on compounds designed to have anti-microbial and anti-fungal properties. This organic synthetic research would center on the production of heterocycles from 1,3 dipolar cycloadditions with nitrile oxides or nitrosilonates as intermediates. The proposed anti-microbial project would involve the challenge of attaching these smaller units together to form a macrocycle that could function as an ionophore. The anti-fungal project would involve an investigation into the synthesis of a novel class of compounds. It is expected that it will be very easy to change a number of variables in these potential polyester macromolecules and isoxazole fungicides. For example the symmetry of the macrocycle could be examined by altering the symmetry of the 3,4-substituents of the tetrahydrofuran ring. The functionality of the macrocyclization could be changed from polyester to polyether to polyamide. Thus there are many variables that could be exploited to produce a series of macrocycles with excellent bindings of metal cations. This research project would be an excellent opportunity for many students interested in both the chemistry and biology behind biomedical research.