SYNTHESIS OF CATIONIC POLYTHIOPHENES TOWARD THERAPEUTIC AGENTS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这项研究的目的是利用荧光共振能量转移(FRET)研究量子点-聚噻吩DNA复合体作为一种将治疗剂输送到特定部位的方法。FRET技术将被用来诱导附着在DNA链上的治疗剂的释放。量子点的使用是为了促进从窄波长的光中吸收能量，由于量子点很难连接到DNA上，导电聚合物聚噻吩被用作能量传递管道。最初的研究将集中在从量子点到DNA的能量转移。随后的研究可能涉及将可光裂解基团连接到复合体的任何部分。我将与南达科他大学化学和生物医学研究系的研究人员合作，我的工作是合成将量子点和DNA链连接起来的聚噻吩类化合物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this research is to investigate quantum dot-polythiophene-DNA complexes as a means to deliver therapeutic agents to site-specific locations using fluorescence resonance energy transfer (FRET). The FRET technique will be used to induce the release of a therapeutic agent that is attached to a strand of DNA. The use of the quantum dot is to facilitate energy absorption from light at narrow wavelengths and the conducting polymer polythiophene is used as an energy-transfer conduit since quantum dots are difficult to attach to DNA. Initial studies will focus on the energy transfer from the quantum dot to the DNA. Following studies may involve attaching photocleavable groups to any part of the complex. I will collaborate with researchers at the University of South Dakota Chemistry and Biomedical Research Departments and my part is to synthesize polythiophenes that will link the quantum dot and the DNA strand.