Nebraska Center for Cellular Signaling

描述（由申请人提供）：本COBRE申请建议继续内布拉斯加州细胞信号中心，该中心的建立是为了加强UNMC特别是牙科学院的研究。该中心的既定目标是：1）扩大目前对细胞信号的关注; 2）增加内布拉斯加州牙科学校的研究概况，最终目标是在NIH资助下进入全国顶级牙科学校;最重要的是，3）为有前途的年轻教师的发展做出贡献，因此，他们将成为科学界的杰出成员，这一点可以从NIH的大量资助、重要手稿的出版、审查小组的服务以及全国各地的演讲邀请中得到证明。 我们已经实现了这些目标，并取得了卓越的成功：我们已经建立了必要的基础设施，包括1）一个有组织的中心，由一个坚定的董事，一个杰出的外部咨询委员会，和一组高度敬业的导师，和2）一个发展计划，旨在加强和维持中心，其中包括研讨会计划，研究生奖学金和种子赠款计划。有了这个地方，我们已经吸引了非常有才华和驱动的初级项目负责人调查相互关联的研究项目，重点是细胞信号的各个方面，并涵盖从发育问题到癌症的疾病状态。作为我们成功的证据，我们已经支持了14名初级项目负责人，其中5人通过NIH R 01机制获得资助，另外2人预计将在下一个资助周期获得资助。此外，我们的初级项目负责人已发表或准备65篇论文和手稿。我们的三位项目负责人在NIH，国防部和美国心脏协会的审查小组中任职，其中几位已被邀请在国家和国际会议上发言。 我们得到了该机构的大力支持，并制定了一项计划，以在COBRE资金到期时维持该计划。参与这一项目的PI和导师致力于在联合国监测委员会内继续培养辅导文化。此外，该中心的形成所带来的合作环境已经并将继续加强内布拉斯加州牙科和医学院的研究基础设施。

DESCRIPTION (provided by applicant): This COBRE application proposes to continue The Nebraska Center for Cellular Signaling that was established to strengthen the research within UNMC and particularly the College of Dentistry. The stated objectives of the Center were 1) to expand the current focus on cellular signaling; 2) to increase the research profile of Nebraska's dental schools, with the ultimate goal of being included in the top dental schools in the country in NIH funding; and, most importantly, 3) to contribute to the development of promising young faculty, so that they will become prominent members of the scientific community as evidenced by significant NIH funding, publication of important manuscripts, service on review panels and invitations to speak across the country. We have accomplished each of these goals with exceptional successful: We have created the necessary infrastructure consisting of 1) An organized Center comprised of a committed director, an outstanding External Advisory Board, and a group of highly dedicated Mentors, and 2) a program of development, designed to enhance and sustain the Center, that includes a seminar program, graduate student stipends and a seed grant program. With this in place, we have attracted highly talented and driven junior Project Leaders investigating inter-related research projects focused on a variety of aspects of cellular signaling, and covering disease states from developmental problems to cancer. As evidence of our success, we have supported 14 junior Project Leaders and have seen five of them funded through the NIH R01 mechanism, with two more expected to be funded in the next funding cycle. In addition, our junior Project Leaders have published or have in preparation 65 papers and manuscripts. Three of our Project Leaders serve on review panels at the NIH, Department of Defense and American Heart Association, and several have been invited speakers at national and international conferences. We have strong support from the institution and a plan in place to sustain the program when the COBRE funding expires. The PI and mentors involved in this project are committed to continuing a culture of mentoring within UNMC. In addition, the collaborative environment resulting from the formation of the Center has and will continue to enhance the research infrastructure within Nebraska's Dental and Medical Schools.