ULTRASTRUCTURE OF THALAMIC INPUTS TO CORTICAL INTERNEURONS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 丘脑的活动触发了广泛的皮层抑制。这并不是因为丘脑神经元是抑制性的（它们释放兴奋性递质谷氨酸），而是因为它们与皮层第四层的抑制性中间神经元形成了强大的突触。我们将研究这些异常强大的连接，在联合光/电子显微镜研究使用染料标记的丘脑输入和他们的突触后中间神经元的目标的超微结构。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Activity in the thalamus triggers widespread cortical inhibition. This is not because thalamic neurons are inhibitory (they release the excitatory transmitter glutamate) but because they form powerful synapses with inhibitory interneurons in Layer IV of the cortex. We will examine the ultrastructure of these unusually strong connections in a joint light/electron microscopic study using dye labeling of both the thalamic inputs and their postsynaptic interneuron targets.