COMPARISONS OF MRI AND DOS IN MEASUREMENTS OF BREAST DENSITY

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 众所周知，乳房X光摄影密度增加乳腺癌的风险是由于(A)额外的荷尔蒙暴露和生理影响，以及(B)遮盖病变。关于MRI乳房密度如何与乳房X光检查乳房密度进行比较的研究很少。更少的人知道DOS是如何受到组织中特定的MRI信号的影响的。 使用借给加州大学旧金山分校乳房成像中心的专用DOS仪器，我们可以共同注册MRI和DOS测量。磁共振成像被用来计算乳房密度，并为乳房内的光传输建模提供3D网格。目的是通过结合各种技术来揭示乳房密度的来源，从而更好地理解MRI和DOS。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Mammographic breast density is known to contribute to breast cancer risk due to (a) additional hormonal exposer and physiological influence, and (b) obscuring of lesions. Little has been investigated as to how MRI breast density may compare with mammographic breast density. Even less is known about how DOS is influenced by specific MRI signatures in tissues. Using a dedicated DOS instrument on loan to the UCSF Breast imaging center, we have co-registered MRI and DOS measurements. The MRI was used to compute breast density as well as provide a 3D mesh for modeling of light transport in the breast. The goal is to understand both MRI and DOS better by combining techniques to reveal the origins of breast density.