CANCER DETECTION VIA MALIGNANCY-SPECIFIC SIGNATURES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 乳腺特异性光谱特征具有检测和表征乳腺病变的潜力，然而，这些光谱特征的全部功能和局限性仍然未知。 我们建议通过测试它们的时间和空间变异性来测试光谱特征，将它们与传统的超声成像以及组织病理学肿瘤特征进行比较。 最终目标将是证明光谱特征可以提高乳腺病变的检测，特别是在标准方法难以检测的人群中（如致密乳腺组织）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Malignancy-specific spectral signatures have the potential to detect and characterize breast lesions.However, the full capabilities and limitations of these spectral signatures remains unknown. We propose to test the spectral signatures by testing their temporal and spatial variability, comparing them with conventional ultrasound imaging as well as histopathological tumor features. The ultimate goal will be to demonstrate that the spectral signatures can improve the detection of breast lesions, particularly in populations where standard methods struggle (such as in dense breast tissue).