DEVELOPMENT OF METABOLIC IMAGING PROBES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 用于改善危重病人的标准微创临床仪器的代谢成像探头的研制 我们的目标是为危重伤员开发救生工具。多年来，我们将加州大学欧文分校开发的漫反射光谱成像(DOSI)技术从研究平台转化为旨在监测新辅助化疗效果的5中心临床试验的尖端。这些在测量乳腺肿瘤对治疗的代谢反应方面有效的技术和方法也可以在传统临床标记物(如动脉血压)注意到之前很好地检测出早期出血。这可以通过感知粘膜组织的代谢/血流动力学状态来实现，例如在食道中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Development of Metabolic Imaging Probes Embedded into Standard Minimally Invasive Clinical Instruments for Improving Critical Care Patient Our goal is to develop life-saving tools for the critically-injured patient. Over the years, we have translated a technique developed at UC Irvine, Diffuse Optical Spectroscopic Imaging (DOSI), from the research bench to the cusp of a 5-center clinical trial designed to monitor the effects of neoadjuvant chemotherapy. These same technologies and approaches that have been effective in measuring breast tumor metabolic response to therapy could also be used to detect early hemorrhage well before traditional clinical markers (such as arterial blood pressure) give notice. This could be accomplished by sensing the metabolic/hemodynamic status of mucosal tissues, such as in the esophagus.