MYOCARDIAL INSULIN RESISTANCE IS NOT WORSENED BY WELL-CONTROLLED HIV INFECTION

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 外周代谢并发症(MC)患者中，胰岛素抵抗与心肌缺血和左心室(LV)功能障碍风险增加之间的关系已被证实，但MC和HIV感染对心肌底物代谢的独立影响及其与LV功能障碍的关系尚不清楚。目的：对合并和不合并心肌肥厚的HIV+和HIV阴性男性心肌葡萄糖和脂肪酸代谢进行量化，并探讨其与左心功能的关系。方法：对23例HIV+MC阳性男性(HIV+/MC+，42±6岁)、15例HIV+非MC男性(HIV+/MC-，41±6岁)、9例HIV阴性MC男性(HIV-/MC+，33±5岁)和22例HIV阴性MC男性(HIV-/MC-，25±6岁)进行心肌葡萄糖利用率(GLUT)、胰岛素利用率(GLUT/INS)、脂肪酸氧化和利用的定量研究。超声心动图测量左心功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The relationship between insulin resistance and increased risk for myocardial ischemia and left ventricular (LV) dysfunction in HIV+ men with peripheral metabolic complications (MC) are established; however the independent effects of MC and HIV infection on myocardial substrate metabolism and their relationship to LV dysfunction are unknown. Objective: To quantify myocardial glucose and fatty acid metabolism and examine the relationship to LV function in HIV+ and HIV-negative men with and without MC. Methods: In 23 HIV+ men with MC+ (HIV+/MC+, 42¿6 yrs), 15 HIV+ men without MC (HIV+/MC-, 41¿6 yrs), 9 HIV-negative men with MC (HIV-/MC+, 33¿5 yrs), and 22 HIV-negative men without MC (HIV-/MC-, 25¿6 yrs), myocardial glucose utilization (GLUT), utilization/serum insulin (GLUT/INS), and fatty acid oxidation and utilization were quantified using 11C glucose, 11C palmitate - and 15O-tracers and myocardial positron emission tomography (PET) imaging. LV function was quantified using echocardiography.