EVALUATION OF INTRAMYOCELLULAR LIPID CONTENT (IMCL) IN SKELETAL MUSCLE BY MRS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 虽然耐力运动员中2型糖尿病患者的肌内脂肪水平相当，但与胰岛素抵抗明显无关。 在未经训练的受试者中，特别是2型糖尿病受试者，肌内脂肪与胰岛素抵抗呈正相关。 在耐力运动员中，肌内脂肪与胰岛素抵抗呈负相关。 我们假设，观察到的矛盾的肌内脂肪与胰岛素抵抗可以解释的差异，在肌内脂肪的物理性质。我们建议通过磁共振光谱来测量这些物理性质的差异

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. While intramyocellular fat levels are comparable between subjects with type 2 diabetes in endurance athletes, there is a marked disassociation with insulin resistance. In untrained subjects, particularly subjects with type 2 diabetes, there is a positive correlation of intramyocellular fat with insulin resistance. In endurance athletes, there is an inverse correlation of intramyocellular fat with insulin resistance. We hypothesize that the observed paradox of intramyocellular fat with insulin resistance can be explained by differences in the physical properties of the intramyocellular fat. We propose to measure these differences in physical properties by magnetic resonance spectroscopy