HYPOGLYCEMIA AND HYPERGLYCEMIA IN DEVELOPING BRAIN

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 低血糖是新生儿常见的代谢性疾病。长期反复的低血糖与长期的海马体功能障碍有关。尽管在人类和动物模型中进行了广泛的研究，但详细的机制尚不清楚，特别是当血糖太低时，不同过程为脑细胞提供燃料的后遗症。本项目的目的是利用9.4T的~1H核磁共振波谱对急性和复发性低血糖时大鼠海马区的神经化学变化进行量化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Hypoglycemia is a common metabolic condition in newborn infants. Prolonged and recurrent hypoglycemia is associated with long-term hippocampal dysfunction. Despite extensive studies in humans and animal models, detailed mechanism is not well understood, especially the sequel of different processes providing fuel for brain cells, when glucose plasma is too low. The purpose of this project is to quantify neurochemical changes during acute and recurrent hypoglycemia on the hippocampus of rat pups using 1H NMR spectroscopy at 9.4 T.