DEVELOPMENT OF AFFECTIVE PROCESSING IN ADOLESCENTS WITH MDD

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本研究旨在验证儿童重性抑郁症（MDD）的病因学和不良结局的发展机制的假设。通过综合的方法，我们建议使用2x2的研究设计检查皮质边缘网络的发展，在年轻和年长的青少年，有和没有MDD。我们建议获得神经影像学数据，包括结构，弥散张量，静息功能和光谱成像。由于我们建议将我们的抑郁症受试者限于那些未接受过治疗的人，我们要求12个月收集这些初步数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project is designed to test the hypothesis that developmental mechanisms underlie the etiology and poor outcomes of pediatric major depressive disorder (MDD). Through an integrative approach, we propose to use a 2x2 study design examine development within cortico-limbic networks in younger and older adolescents, with and without MDD. We propose to obtain neuroimaging data including stuctural, diffusion tensor, resting functional, and spectropscopic imaging. Since we have proposed to limit our depressed subjects to those who are treatment-naive, we request 12 months to collect this pilot data.