Exploring the Neural Circuitry of Deliberate Self Harm in Adolescents

探索青少年故意自残的神经回路

• 批准号: 8460471
• 负责人: Kathryn Regan Cullen
• 金额: $ 18.24万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-19 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8460471
• 关键词: Adjustment Disorders; Adolescence; Adolescent; Age; Amygdaloid structure; Anterior; Anxiety Disorders; Behavior; Biological Neural Networks; Borderline Personality Disorder; Brain; Brain imaging; Brain region; Clinical; Conscious; Control Groups; Development; Diagnosis; Diagnostic; Diffusion Magnetic Resonance Imaging; Dimensions; Disease; Early Intervention; Eating Disorders; Emotions; Female Adolescents; Foundations; Fright; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Laboratories; Light; Link; Longitudinal Studies; Major Depressive Disorder; Maps; Measures; Mediating; Mental disorders; Methods; Modeling; Neurobiology; Neuronal Plasticity; Outcome; Pain; Pattern; Pharmaceutical Preparations; Pilot Projects; Population; Prevalence; Process; Psychiatry; Psychopathology; Public Health; Recording of previous events; Research; Rest; Risk; Self-Injurious Behavior; Severities; Subconscious; Substance abuse problem; Suicide; Suicide attempt; Symptoms; System; Thalamic structure; Time; United States National Institutes of Health; aged; base; brain behavior; cingulate cortex; emotion regulation; girls; improved; meetings; neural circuit; neurobiological mechanism; neurodevelopment; non-suicidal self injury; prevent; psychologic; relating to nervous system; reward processing; scaffold; self esteem; stem; tool; treatment response; treatment strategy; young woman

DESCRIPTION (provided by applicant): The goal of this brain imaging study is to examine brain connectivity in adolescent girls with non-suicidal self- injury (NSSI). To date, little is knwn about the neurobiological underpinnings of NSSI. This behavior occurs in a wide range of conditions including major depressive disorder (MDD), borderline personality disorder (BPD), anxiety disorders, substance abuse disorders, adjustment disorders and eating disorders. Conversely, many adolescents with NSSI do not meet criteria for any psychiatric disorders. Thus, the field has begun to consider NSSI not as a symptom of a specific disorder, but as an entity in its own right. Our laboratory has been developing methods to examine the connections within brain networks (connectivity) using diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI). These tools allow for the application of systems-based approaches to examining the neural underpinnings of psychopathology, a recent priority in the field. Thus, instead of examining specific brain regions, recent research has been focused on characterizing connectivity within neural circuitry. Examination of brain connectivity is particularly relevant to studying problems that emerge in adolescence given the ongoing maturation of connections within relevant brain systems during this time period. The hypothesis of the current study is that aberrant neural circuitry underlies the tendency to engage in NSSI in adolescents. As we examine brain connectivity in this group, we will explore key psychological dimensions such as emotion regulation (and others) that could mediate the link between circuitry abnormalities and NSSI. In keeping with the NIH initiative RDoC, we focus not on diagnosis but on a specific behavior (i.e., NSSI); to increase homogeneity of the NSSI group we will include several constraints: medication-naive, girls only, a narrow range of age and pubertal development, and no history of SA. This project may represent the first study to examine neural circuitry of NSSI in adolescents, and thus will be a major step forward in uncovering neurobiological mechanisms that underlie NSSI. Elucidating the neural correlates of NSSI is especially important during adolescence; early intervention during a time of increased neuroplasticity could prevent entrenchment of aberrant behavior and promote healthy neurodevelopment. This project will provide the foundation for future longitudinal studies that will examine (a) predictors for course of psychopathology and treatment response, and (2) the impact of treatment on aberrant connectivity patterns in adolescents with NSSI (i.e., mechanisms of successful treatment.)

描述（由申请人提供）：本脑成像研究的目的是检查非自杀性自伤（NSSI）的青春期女孩的大脑连通性。迄今为止，人们对自伤的神经生物学基础知之甚少。这种行为发生在很多情况下，包括重度抑郁症（MDD）、边缘型人格障碍（BPD）、焦虑症、药物滥用障碍、适应障碍和饮食障碍。相反，许多青少年自伤不符合任何精神疾病的标准。因此，该领域已经开始考虑自伤，而不是作为一种特定疾病的症状，而是作为一个独立的实体。我们的实验室一直在开发使用扩散张量成像（DTI）和功能磁共振成像（fMRI）来检查大脑网络（连通性）内的连接的方法。这些工具允许应用基于系统的方法来检查精神病理学的神经基础，这是该领域最近的一个优先事项。因此，最近的研究主要集中在表征神经回路内的连通性，而不是检查特定的大脑区域。大脑连通性的检查与