SIMULATION OF CORONARY ARTERY BYPASS GRAFT AND SURGICAL VENTRICULAR RESTORATION

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 该项目的总体目标是开发和部署一个公共领域 软件工具，使心脏外科医生和心血管疾病研究人员能够 模拟冠状动脉旁路移植术(CABG)和外科心脏手术的效果 缺血性心力衰竭患者的康复(SVR)。我们的目标是： 1.对10例STICH患者依次进行术前术后CT、MRI检查 为了量化他们的室壁几何形状和局部功能以及冠状动脉解剖和 血液流动。 2.仅使用公共领域软件开发基于物理的CABG和SVR模拟。 假设：在患者的治疗中，SVR+CABG比单独CABG更有益处 伴有缺血性心力衰竭。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall objective of this project is to develop and deploy a public-domain software tool that will enable cardiac surgeons and cardiovascular disease researchers to simulate the effects of coronary artery bypass graft (CABG) and surgical ventricular restoration (SVR) on patients with ischemic heart failure. The aims are to: 1. Obtain pre- and post-operative CT and MRI exams on STICH patients (n = 10) in order to quantify their LV wall geometry and regional function and coronary artery anatomy and blood flow. 2. Develop physics-based simulations of CABG and SVR using only public-domain software. Hypothesis: There is a benefit of SVR + CABG over CABG alone in the treatment of patients with ischemic heart failure.