INTRACELLULAR ACTIN DYNAMICS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 肌动蛋白的组装和拆卸被认为是在细胞前沿驱动运动的机制的关键组成部分。许多关键的调节分子已经被确定，它们之间的相互作用已经被定量。这使得该系统成为建模和仿真的理想选择。然而，目前尚不清楚是否所有的参与者都是真正已知的，因此模型可以帮助确定系统是否足够确定，以便能够解释整个系统的行为。虚拟细胞是一个理想的平台，用于建立一个层次化的模型集，可以捕捉系统的复杂性，在一个有序的进展，并直接参考验证实验。这个问题将推动虚拟细胞技术的发展，使其能够正确地表示和模拟聚合反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Actin assembly and disassembly are thought to be key components of the machinery that drives motility at the cell leading edge. Many of the key regulatory molecules have been identified and their interactions have been quantitated. This makes this system ideal for modeling and simulation. However, it is not clear if all of the players are truly known, so a model can aid in establishing whether the system is sufficiently determined to be able to explain the overall system behavior. Virtual cell is an ideal platrform for building a hierarchical set of models that can capture the complexity of the system in an orderly progression and with direct reference to validating experiments. This problem will drive the technological development of Virtual Cell toward being able to properly represent and simulate polymerization.