ATOMIC RESOLUTION STRUCTURE AND FUNCTION OF THE RIBOSOME

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这一子项目旨在确定E.Coli70S核糖体在翻译、延长、终止和核糖体回收的不同步骤中的结构。细菌核糖体在这些不同的翻译步骤中的原子分辨结构将有助于未来针对核糖体的抗生素的开发。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This subproject is aimed at determining the structure of the E. coli 70S ribosome in different steps of translation elongation, termination and ribosome recycling. Atomic-resolution structures of the bacterial ribosome in these various steps of translation will aid in the the future development of antibiotics that target the ribosome.