T CELL RECEPTOR RECOGNITION IN MOLECULAR AND CANCER IMMUNOLOGY

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 收集了研究T细胞受体(TCR)识别的基本特性和用于癌症基因治疗的TCR对肿瘤抗原的识别的项目的数据。这些项目的目的包括(1)研究抗原修饰的生物物理后果，目的是了解肿瘤特异性TCR的识别；(2)研究与肿瘤排斥反应相关的TCR-肽/MHC三元复合体的结构特性；(3)研究未连接的TCR的结构特性，以了解结合环的构象特性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Data were collected on projects studying the basic properties of T cell receptor (TCR) recognition and the recognition of tumor antigens by TCRs used in the gene therapy of cancer. The aim of the projects included (1) studying the biophysical consequences of antigen modification with the goal of understanding recognition by tumor specific TCRs, (2) studying the structural properties of TCR-peptide/MHC ternary complexes associated with tumor rejection, and (3) studying the structural properties of an unligated TCR to gain insight into conformational properties of binding loops.