DVMT COMPUTATIONAL AND BIOINFORMATICS CAPABILITIES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 核心3下的努力解决了与测量方法的进步相关的挑战，包括使用高通量多维分离和完整蛋白质测量的更大作用，以提供更多关于蛋白质修饰状态的信息。核心3的目标旨在： +改进和完善肽/蛋白质鉴定流程，包括提供统计上合理的高质量指标。 +为蛋白质组学中改进的定量以及相关的质量指标提供基础。 +开发或评估整合“组学”数据所需的生物信息学工具，并促进中心核心技术和方法的应用，以支持协作应用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Efforts under Core 3 addressed the challenges associated with advances in measurement approaches, including the use of high throughput multidimensional separations and a greater role for intact protein measurements to provide more information on protein modification states. The Aims in Core 3 were designed to: +Improve and refine peptide/protein identification processes, which included providing statistically sound, high-quality metrics. +Provide the basis for improved quantification in proteomics in conjunction with associated quality metrics. +Develop or evaluate the bioinformatics tools needed to integrate "-omics" data and facilitate application of the Center's Core technologies and approaches in support of collaborative applications.