ANALYSIS OF THE ORB6 KINASE-ASSOCIATED PROTEIN COMPLEX

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 在哺乳动物细胞中，保守激酶NDR的表达或调节改变与癌症进展有关。 目前，关于NDR激酶效应子的信息非常有限。在分裂酵母中，NDR同源物Orb 6在控制细胞形态和增殖中具有明确的作用。新的Orb 6相互作用因子的鉴定将提供对保守信号通路的功能的深入了解，该信号通路在许多生物体（包括人类细胞）的生长控制中具有作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In mammalian cells, altered expression or regulation of the conserved kinase NDR has been linked to cancer progression. At the moment there is very limited information on NDR kinase effectors. In fission yeast, the NDR homologue Orb6 has a clear role in the control of cell morphology and proliferation. The identification of novel Orb6-interacting factors will provide insight into the function of a conserved signaling pathway that has a role in growth control in many organisms, including human cells.