ANALYSIS OF THE ORB6 KINASE-ASSOCIATED PROTEIN COMPLEX

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在哺乳动物细胞中，保守的激酶NDR的表达或调节的改变与癌症的进展有关。目前，关于NDR激酶效应器的信息非常有限。在裂解酵母中，NDR同源基因Orb6对细胞形态和增殖有明显的调控作用。新的Orb6相互作用因子的发现将使我们深入了解保守的信号通路的功能，该通路在包括人类细胞在内的许多生物体中起着生长控制的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In mammalian cells, altered expression or regulation of the conserved kinase NDR has been linked to cancer progression. At the moment there is very limited information on NDR kinase effectors. In fission yeast, the NDR homologue Orb6 has a clear role in the control of cell morphology and proliferation. The identification of novel Orb6-interacting factors will provide insight into the function of a conserved signaling pathway that has a role in growth control in many organisms, including human cells.