ANALYSIS OF THE ORB6 KINASE-ASSOCIATED PROTEIN COMPLEX

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 在哺乳动物细胞中，保守激酶NDR的表达或调节改变与癌症进展有关。 目前，关于NDR激酶效应子的信息非常有限。在分裂酵母中，NDR同源物Orb 6在控制细胞形态和增殖中具有明确的作用。新的Orb 6相互作用因子的鉴定将提供对保守信号通路的功能的深入了解，该信号通路在许多生物体（包括人类细胞）的生长控制中具有作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In mammalian cells, altered expression or regulation of the conserved kinase NDR has been linked to cancer progression. At the moment there is very limited information on NDR kinase effectors. In fission yeast, the NDR homologue Orb6 has a clear role in the control of cell morphology and proliferation. The identification of novel Orb6-interacting factors will provide insight into the function of a conserved signaling pathway that has a role in growth control in many organisms, including human cells.