ANALYSIS OF THE ORB6 KINASE-ASSOCIATED PROTEIN COMPLEX

ORB6 激酶相关蛋白复合物的分析

• 批准号: 8171296
• 负责人: FULVIA VERDE
• 金额: $ 0.24万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171296
• 关键词: Cells; Cellular Morphology; Computer Retrieval of Information on Scientific Projects Database; Fission Yeast; Funding; Grant; Growth; Homologous Gene; Human; Institution; Link; Mammalian Cell; Organism; Phosphotransferases; Regulation; Research; Research Personnel; Resources; Role; Signal Pathway; Source; United States National Institutes of Health; insight; novel; protein complex; tumor progression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In mammalian cells, altered expression or regulation of the conserved kinase NDR has been linked to cancer progression. At the moment there is very limited information on NDR kinase effectors. In fission yeast, the NDR homologue Orb6 has a clear role in the control of cell morphology and proliferation. The identification of novel Orb6-interacting factors will provide insight into the function of a conserved signaling pathway that has a role in growth control in many organisms, including human cells.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 在哺乳动物细胞中，保守激酶 NDR 的表达或调节改变与癌症进展有关。 目前有关 NDR 激酶效应物的信息非常有限。在裂殖酵母中，NDR 同源物 Orb6 在细胞形态和增殖的控制中具有明显的作用。新型 Orb6 相互作用因子的鉴定将有助于深入了解保守信号通路的功能，该通路在包括人类细胞在内的许多生物体的生长控制中发挥作用。