TOWARDS THE COMPLETE CHARACTERIZATION OF NEUREXIN TRANS-SYNAPTIC LIGANDS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 跨突触黏附蛋白质组的鉴定和鉴定可能足以破解突触密码。跨突触黏附蛋白质组的测定可能被证明是我们最终理解神经元突触电路和脑连接以及反过来生物体行为的核心。从历史上看，Neurexins(NRXns)被认为是最有可能导致突触后分化的突触前蛋白。NRXN蛋白的表达受到高度调控(3个基因、不同的启动子和大量的不同剪接)，有人认为NRXN在哺乳动物的大脑中可能以数千种不同的形式存在。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The identification and characterization of the trans-synaptic adhesion proteome may prove sufficient to break the synapse code. Determination of the trans-synaptic adhesion proteome may prove central to our eventual understanding of neuronal synaptic circuitry and brain wiring and in turn organism behavior. Historically, Neurexins (NRXNs) have been considered the most-likely presynaptic protein responsible for post-synaptic differentiation. NRXN protein expression is highly regulated (3 genes, alternative promoters, and massive alternative splicing) and it has been proposed that NRXNs may be present in thousands of isoforms within the mammalian brain.