Molecular and Cellular Mechanisms underlying function and dysfunction of Neural C

描述（由申请人提供）：本申请旨在招募跨学科项目的新研究人员，其重点是健康和疾病中的神经回路的结构和功能。神经回路与行为（PNCB）计划将：1)深入探索神经回路的生物学及其产生的行为；2)使用高度跨学科的方法解决该领域最重要的问题。PNCB建立在一个非常丰富的神经科学社区的基础上，该社区有120多名成员，分别位于加州大学圣地亚哥分校、索尔克研究所、斯克里普斯研究所和伯纳姆研究所。PNCB是医学院通过神经科学系和生物科学系通过神经生物学部门联合创建的。该科主任（Anirvan Ghosh）和该系主任（William Mobley）已将精力和资源投入到他们认为神经科学下一步最重要的工作中——“破译正常大脑和受神经系统疾病影响的大脑中的神经回路的结构和功能”。PNCB现有成员有Robert Malinow， Jeffrey Isaacson和Massimo Scanziani。所有这些都占据了CMG大楼的空间；新聘人员也将设在那里，以加强职业发展的各个方面。其中一名新成员将开发和使用新的光遗传学工具用于成像功能。另一项研究将检查小鼠模型的电路功能，包括疾病模型。因此，他们将为加州大学圣地亚哥分校带来新的技术和概念，同时从一个培育神经科学社区中受益匪浅。PNCB还将包括大约20名来自更大社区的成员，他们的工作是在从基因到高级行为的神经回路分析层面上。通过在PNCB成员与加州大学圣地亚哥分校的临床医生和科学家（如化学、药物化学、物理和心理学）之间建立密切联系，这个新项目无疑将培养许多关于神经回路生物学的新见解。事实上，我们期望我们的新成员和他们的同事能够改变我们对神经回路的组织和功能的理解。

DESCRIPTION (provided by applicant): This application targets the recruitment of new investigators o an interdisciplinary program whose focus is the structure and function of neural circuits in health and disease. The Program in Neural Circuits and Behavior (PNCB) will: 1) explore intensively on the biology of neural circuits and the behaviors they produce; and 2) tackle the most important questions in this field using a highly interdisciplinary approach. The PNCB builds on an extraordinarily rich neurosciences community of more than 120 members located at UCSD as well as at the Salk Institute, Scripps Research Institute, and the Burnham Institute. The PNCB is a recent joint creation of the School of Medicine, through the Department of Neurosciences, and the Division of Biological Sciences, through the Section on Neurobiology. The Chairs of the Section (Anirvan Ghosh) and the Department (William Mobley) have committed energy and resources to what they view as the most important next step for the neurosciences -" to decipher the structure and function neural circuits in the normal brain and in brains affected by neurological disorders". PNCB existing members are Robert Malinow, Jeffrey Isaacson and Massimo Scanziani. All occupy space in the CMG building; the new recruits would also be located there to enhance all aspects of career development. One of the new recruits would develop and use new optogenetic tools for imaging function. The other would examine circuit function in mouse models, including models of disease. Thus, they would bring new technologies and concepts to UCSD while benefitting immensely from a nurturing neuroscience community. The PNCB will also include about 20 additional members of the greater community whose work is in neural circuits at levels of analysis ranging from genes to higher order behaviors. By establishing close links between PNCB members and clinicians and scientists in the greater UCSD campus (e.g. Chemistry, Pharmaceutical Chemistry, Physics, and Psychology), this new program will undoubtedly foster many new insights into the biology of neural circuits. Indeed, it is our expectation that our recruits and their colleagues will transform our understanding of the organization and function of neural circuits. PUBLIC HEALTH RELEVANCE: All brain functions are carried out through the activation of specific neural circuits. Conversely, all disorders of brain function are due to disruption of specific circuits. Because we know little about the structure and function of neural circuits, we do not understand how circuits fail in brain disorders. Herein we propose to recruit key members of a multidisciplinary team to explore the function of circuits in health and disease.