Molecular and Cellular Mechanisms underlying function and dysfunction of Neural C

神经 C 功能和功能障碍的分子和细胞机制

• 批准号: 7859550
• 负责人: ANIRVAN GHOSH
• 金额: $ 71.41万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7859550
• 关键词: Molecular; Cellular; Mechanisms; underlying; function

DESCRIPTION (provided by applicant): This application targets the recruitment of new investigators o an interdisciplinary program whose focus is the structure and function of neural circuits in health and disease. The Program in Neural Circuits and Behavior (PNCB) will: 1) explore intensively on the biology of neural circuits and the behaviors they produce; and 2) tackle the most important questions in this field using a highly interdisciplinary approach. The PNCB builds on an extraordinarily rich neurosciences community of more than 120 members located at UCSD as well as at the Salk Institute, Scripps Research Institute, and the Burnham Institute. The PNCB is a recent joint creation of the School of Medicine, through the Department of Neurosciences, and the Division of Biological Sciences, through the Section on Neurobiology. The Chairs of the Section (Anirvan Ghosh) and the Department (William Mobley) have committed energy and resources to what they view as the most important next step for the neurosciences -" to decipher the structure and function neural circuits in the normal brain and in brains affected by neurological disorders". PNCB existing members are Robert Malinow, Jeffrey Isaacson and Massimo Scanziani. All occupy space in the CMG building; the new recruits would also be located there to enhance all aspects of career development. One of the new recruits would develop and use new optogenetic tools for imaging function. The other would examine circuit function in mouse models, including models of disease. Thus, they would bring new technologies and concepts to UCSD while benefitting immensely from a nurturing neuroscience community. The PNCB will also include about 20 additional members of the greater community whose work is in neural circuits at levels of analysis ranging from genes to higher order behaviors. By establishing close links between PNCB members and clinicians and scientists in the greater UCSD campus (e.g. Chemistry, Pharmaceutical Chemistry, Physics, and Psychology), this new program will undoubtedly foster many new insights into the biology of neural circuits. Indeed, it is our expectation that our recruits and their colleagues will transform our understanding of the organization and function of neural circuits. PUBLIC HEALTH RELEVANCE: All brain functions are carried out through the activation of specific neural circuits. Conversely, all disorders of brain function are due to disruption of specific circuits. Because we know little about the structure and function of neural circuits, we do not understand how circuits fail in brain disorders. Herein we propose to recruit key members of a multidisciplinary team to explore the function of circuits in health and disease.

描述（由申请人提供）：本申请旨在招募一个跨学科项目的新研究人员，其重点是健康和疾病中神经回路的结构和功能。神经回路和行为计划（PNCB）将：1）深入探索神经回路的生物学及其产生的行为; 2）使用高度跨学科的方法解决该领域最重要的问题。PNCB建立在一个非常丰富的神经科学社区上，该社区由位于UCSD以及Salk研究所，Scripps研究所和Burnham研究所的120多名成员组成。PNCB是医学院最近通过神经科学系和生物科学系通过神经生物学科联合创建的。该科的主席（Anirvan Ghosh）和系主任（William Mobley）将精力和资源投入到他们认为神经科学最重要的下一步-“破译正常大脑和受神经系统疾病影响的大脑中的结构和功能神经回路”。PNCB现有成员是Robert Malinow、Jeffrey Isaacson和Massimo Scanziani。所有人员都在CMG大楼内办公;新征聘人员也将在那里办公，以加强职业发展的各个方面。其中一名新成员将开发和使用新的光遗传学工具来实现成像功能。另一个将检查小鼠模型中的电路功能，包括疾病模型。因此，他们将为UCSD带来新的技术和概念，同时从培育神经科学社区中受益匪浅。PNCB还将包括大约20名更大社区的成员，他们的工作是在从基因到高阶行为的分析水平上的神经回路。通过建立PNCB成员和临床医生和科学家之间的密切联系，在更大的UCSD校园（例如化学，药物化学，物理学和心理学），这个新计划无疑将促进许多新的见解神经回路的生物学。事实上，我们期望我们的新员工和他们的同事能够改变我们对神经回路的组织和功能的理解。 公共卫生相关性：所有的大脑功能都是通过激活特定的神经回路来实现的。相反，所有的大脑功能障碍都是由于特定回路的中断。因为我们对神经回路的结构和功能知之甚少，我们不明白大脑疾病中的回路是如何失效的。在此，我们建议招募一个多学科团队的关键成员，以探索健康和疾病中的电路功能。