SIGNAL TRANSDUCTION

信号转导计划(STP)的总体目标是阐明支配 信号通路的激活和抑制在正常发育、肿瘤转化和 肿瘤进展。这一目标的前提是信号转导的异常是普遍存在的。 人类癌细胞的特征，几乎反映了转化表型的所有方面。成员： 信号转导计划目前从事三个主要研究领域：(1)激酶和 在肿瘤发展中重要并已知在人类肿瘤中经历变化的磷酸酶；(2) 泛素连接酶和泛素样蛋白在解除调控的细胞通路中发挥重要作用 在肿瘤的发展和进展过程中；和(3)代谢信号改变的一个新的主题 癌症。 信号转导计划成立于2001年，自去年以来得到了极大的加强 通过招聘具有补充原有利益的专业知识的新教员来续签 教职员工。在16名现有成员中，有11名成员是自2003年以来招募的。其中包括 Ze‘ev Ronai博士，他于2004年被聘为信号转导项目的新项目负责人。 该计划具有高度的协作性和互动性，联合实验室会议、联合 指导研究生和博士后研究员，青年教师联合指导方案，每月 博士后报告，每月教职员工会议，每月兴趣小组(泛素，ER压力) 会议，一年一度的博士后务虚会，以及几个项目资助计划正在进行中。作为一名 作为这些活动的结果，计划成员领导或参与了4个POL助学金(2个来自NCI)，分多次 共享联邦和州拨款，以及多份共同撰写的出版物。该计划的高生产率 在过去的授权期内，该计划持有的21项ROI奖励(7项来自NCI)进一步证明了这一点 会员；通过目前1450万美元的年度赠款资金总额(820万美元直接)；通过392种出版物 上一次审查，以及2008年65份计划出版物，占计划内和计划间的11%和31% 分别是协作。

The overall goal of the Signal Transduction Program (STP) is to elucidate the mechanisms that govern activation and repression of signaling cascades during normal development, neoplastic transformation and tumor progression. This goal is based on the premise that abnormalities in signal transduction are universal features of human cancer cells, and underiie virtually all aspects of the transformed phenotype. Members of the Signal Transduction Program currently pursue three major investigative areas: (1) kinases and phosphatases that are important in tumor development and known to undergo changes in human tumors; (2) ubiquitin ligases and ubiquitin-like proteins that play important roles in cellular pathways that are deregulated during tumor development and progression; and (3) an emerging theme of altered metabolic signaling in cancer. The Signal Transduction Program was established in 2001, and has been greatly strengthened since the last renewal by recruitment of new faculty members with expertise that complements the interests of the original faculty members. Of the 16 current members, 11 members have been recruited since 2003. Among them is Dr. Ze'ev Ronai, who was recruited as new Program Leader for the Signal Transduction Program in 2004. The Program is highly collaborative and interactive as evidenced by joint laboratory meetings, joint mentoring of graduate students and postdoctoral fellows, joint mentoring program for young faculty, monthly postdoctoral fellow presentations, monthly faculty meetings, monthly interest group (ubiquitin, ER stress) meetings, the annual postdoctoral retreat, and several Program Project grant initiatives underway. As a result of these activities, Program members lead or participate in 4 POl grants (2 from NCI), in multiple shared federal and state grants, and multiple co-authored publications. The high productivity of the Program during the past grant period is further documented by 21 ROI grants (7 from NCI) held by the Program members; by the current total annual grant funding of $14.5MM ($8.2MM direct); by 392 publications since last review, and by 65 Program publications in 2008, which represent 11% of intra- and 31% of interprogrammatic collaborations, respectively.