Inflammation in Innate and Adaptive Immune Mechanisms

描述（由申请人提供）：白细胞生物学学会年会是一个主要的科学学会，致力于研究感染或损伤引起的免疫激活以及该反应的组织和控制，其传统是突出在宿主-病原体相互作用机制，创伤或损伤导致的失调以及疾病发病机制中的白细胞功能方面最具创新性和及时的工作。2012年的“先天性和适应性免疫机制中的炎症”会议将继续这一传统，将各级科学研究人员聚集在一个旨在最大限度地相互作用和交流思想的环境中。目的1。提供资金，以扩大参加白细胞生物学学会年会的人数，为学员提供旅行奖励，并增加额外与会者的能力。会议是一个论坛，约有300-350名来自世界各地的学术、政府和工业实验室的参与者，将包括对炎症反应新兴概念的介绍和讨论，因为它们影响先天和适应性免疫。这些将包括(1)新的模式识别受体的鉴定，(2)上皮在炎症反应启动中的作用以及与适应性免疫的联系，(3)炎症反应传播中炎症小体功能的新特征，(4)肿瘤浸润髓样细胞在炎症和癌症之间的联系中的重要性，以及(5)代谢控制在淋巴细胞分化和功能中的贡献。该计划将包括邀请该领域的领导者的演讲，以及初级研究人员和学员的海报演讲，以及从世界各地实验室提交的摘要中选出的口头演讲。目标2。提供额外的科学规划内容，涵盖先天性和适应性免疫系统的不同细胞群的调节，激活和功能的新发展。这将通过专注于巨噬细胞和树突状细胞的会议来完成。T细胞、NK细胞、B细胞、Th17和Treg细胞。此外，白细胞功能方面也将包括在该计划中，并将捕捉细胞因子信号，炎症基因表达的转录后调节，宿主病原体相互作用以及免疫和神经科学的联系方面的新进展。酒精和免疫学研究兴趣小组将在SLB会议开幕前一天组织一次会前卫星专题讨论会，重点讨论酒精对炎症和免疫信号传导方面的影响。我们的会议将扩大对卫星会议与会者的基础和临床免疫学的了解。目标3。为年轻的研究人员和学员提供机会，与各自领域的知名研究人员进行正式和非正式的密切互动，并在海报和讲台/口头会议上展示他们的研究成果。目标4。为妇女、代表性不足的少数群体成员和残疾人提供参加会议的机会，以展示和促进他们的工作

Description (as provided by the applicant): The annual meeting of Society for Leukocyte Biology, a leading scientific society addressing immune activation by infection or injury and the organization and control of that response, has a tradition of highlighting the most innovative and timely work on the mechanisms underlying host-pathogen interactions, dysregulation as a result of trauma or injury and leukocyte functions in the pathogenesis of disease. The 2012 meeting "Inflammation in Innate and Adaptive Immune Mechanisms" will continue this tradition by bringing together scientific researchers of all levels in an environment geared to maximize interactions and the exchange of ideas. Objective 1. To provide funding to expand the number of individuals that can attend the annual meeting of the Society of Leukocyte Biology, by providing travel awards for trainees and increase the capacity for additional attendees. The meeting is a forum for approximately 300-350 participants from academic, governmental, and industrial laboratories worldwide that will include presentation and discussion of emerging concepts in inflammatory response as they impact on innate and adaptive immunity. These will include (1) identification of new pattern recognition receptors, (2) the role of the epithelium in initiation of inflammatory response and the connection to adaptive immunity, (3) new features of inflammasome function in propagation of inflammatory response, (4) the emerging importance of tumor infiltrating myeloid cells in the link between inflammation and cancer, and (5) the contribution of metabolic controls in lymphoid differentiation and function. The program will feature presentations by invited leaders in the field, as well as poster presentations by junior investigators and trainees and oral presentations selected from among the abstracts submitted by laboratories worldwide. Objective 2. To provide additional scientific programmatic content covering new developments in the regulation, activation and function of the diverse cell populations of the innate and adaptive immune system. This will be accomplished through sessions focused on macrophages and dendritic cells, ?/¿ T cells and NK cells, B cells, and Th17 and Treg cells. In addition, aspects of leukocyte functionality will also be included in the program and will capture new developments in cytokine signaling, post-transcriptional regulation of inflammatory gene expression, host pathogen interactions, and the connection of immunity and neuroscience. A pre-meeting satellite symposium focused on the impact of alcohol on aspects of signaling in inflammation and immunity will be organized by the Alcohol and Immunology Research Interest Group and will occur the day before the opening of the SLB conference. Our meeting will broaden exposure of basic and clinical immunology to the attendees of the satellite meeting. Objective 3. To provide an opportunity for young investigators and trainees to interact closely with well- established researchers in their fields both formally and informally and to present their research in both poster and podium/oral sessions. Objective 4. To provide an opportunity for women, members of under-represented minority groups, and persons with disabilities to participate in a meeting that showcases their work and facilitates one on one interactions with other scientists in their fields, as well as providing a forum to address obstacles and explore solutions that will optimize their success. Public Health Relevance: The scientific advances in the complementary and interactive fields of inflammation, innate immunity, infectious disease and inflammatory disorders continue to accelerate with novel findings and implications for human health. The annual conference of the Society for Leukocyte Biology in 2012 will provide a much needed opportunity for a highly productive exchange of scientific information on the latest advances and best work in these fields, which have enormous relevance to a broad range of clinical disorders currently prevalent in the US and worldwide populations. Moreover, the conference will strongly promote effective interactions among scientists from different fields, between established and developing junior investigators, and with women and minority scientists with the hope of developing productive collaborations and/or accelerating research productivity and success.