VALIDATION OF THE IPQ-R ADAPTED FOR COLORECTAL CANCER RISK

描述（由申请人提供）：结直肠癌（CRC）是美国第三大常见癌症和癌症死亡原因。尽管有循证筛查和预防CRC的方法，但筛查依从率一直不理想。大多数旨在增加CRC筛查（CRCS）的行为干预措施都取得了有限的成功。基于理论模型的干预措施，如Leventhal的自我调节模型（或疾病表征的常识模型），结合了认知和情绪对行为的影响，可能对促进癌症筛查行为更有效。理解疾病表征（即，原因、控制、时间轴、后果、身份、连贯性、情感）是特别有价值的，因为它确定了干预的目标，以重建与疾病有关的信念，这将导致更有利的健康行为和疾病结果。它还可以提高对具体信息的接受程度，从而提高基于卫生传播的干预措施的有效性。很少有研究像我们在目前的研究中提出的那样，在健康个体中检查疾病威胁或健康风险的疾病表征。此外，在少数几项研究中，检查疾病风险表示，使用不同的措施，并不是所有领域的评估，在每一项研究中，这突出了需要标准，验证措施的疾病风险表示健康的人。修订的疾病感知问卷（IPQ-R）已适用于许多疾病和病症，并用于诊断和健康个体，但不适用于CRC或CRC风险。IPQ-R的批评表明，简单的调整将产生不精确的措施，并未能捕捉疾病特异性的信念，因此，我们扩展了IPQ-R，包括额外的项目和分量表的基础上，我们的形成工作和文献综述。该研究的目的是产生一种新的有效工具来衡量CRC风险的疾病代表。我们将通过一个大型的横断面调查来实现这一目标，以解决以下具体目标：目标1）确定因素结构目标2）确定适用于CRC风险的新IPQ-R在由性别、种族、糖尿病状态和CRCS状态定义的特定亚组中的测量等效性;和目的3）检查适用于CRC风险的新IPQ-R的结构有效性和其他相关性。新工具将成为研究人员的重要资源，用于确定改善干预研究的新途径，以增加CRCS和其他癌症预防行为，从而降低CRC发病率和死亡率。

DESCRIPTION (provided by applicant): Colorectal cancer (CRC) is the third most common cause of cancer and cancer death in the USA. Despite the availability of evidence-based screening and prevention methods for CRC, rates of screening adherence have been suboptimal. Most behavioral interventions designed to increase CRC screening (CRCS) have had limited success. Interventions based on a theoretical model such as Leventhal's Self-Regulation Model (or Common-Sense Model of Illness Representations) that incorporates both the cognitive and emotional influences on behavior may be more effective for promoting cancer screening behaviors. Understanding illness representations (i.e., cause, control, timeline, consequences, identity, coherence, emotional) is particularly valuable because it identifies targets for interventions to restructure disease-related beliefs, which then would lead to more favorable health behaviors and disease outcomes. It also may increase receptivity to specific messages, thereby improving the effectiveness of health communication-based interventions. Few studies have examined illness representations for disease threats or health risks among healthy individuals, as we propose in the current study. Additionally, among the few studies that have examined illness risk representations, different measures are used and not all domains are assessed in every study, which highlights the need for standard, validated measures of illness risk representations among healthy persons. The Revised Illness Perceptions Questionnaire (IPQ-R) has been adapted for numerous diseases and conditions and used with diagnosed and healthy individuals, but not CRC or CRC risk. Critiques of the IPQ-R suggest that simple adaptations will produce imprecise measures and fail to capture disease-specific beliefs; therefore, we extended the IPQ-R to include additional items and subscales based on our formative work and reviews of the literature. The objective of the study is to produce a novel validated instrument to measure illness representations of CRC risk. We will accomplish this with a large cross-sectional survey to address the following specific aims: Aim 1) Determine the factor structure (number of domains) of the new IPQ-R adapted for CRC risk; Aim 2) Determine the measurement equivalence of the new IPQ-R adapted for CRC risk across specific subgroups defined by gender, race, diabetes status, and CRCS status; and Aim 3) Examine the construct validity and additional correlates of the new IPQ-R adapted for CRC risk. The new instrument will be an important resource for researchers for identifying new avenues for improving intervention research to increase CRCS and other cancer prevention behaviors which would then reduce CRC morbidity and mortality.