Immunoincompetent Rodent and Biohazard Facility

癌症研究所隔离设施(CCIF)，其中容纳了免疫能力不强的啮齿动物和 生物遏制设施是杜克综合癌症研究所最古老的共享资源。这 设施为癌症研究所的研究人员提供专门的隔离实验室，用于危险工作 生物分子，某些重组DNA程序，以及用于维持免疫抑制和 无特定病原体的啮齿动物或其他需要生物安全2级和3级遏制措施的实验 需要研究癌症生物学和治疗。该建筑总面积为3万平方英尺， 包括8个模块，包括3个带铅衬里的房间、2个Horsfall房间、24个动物收容室、8个 实验室、机械设备支持区、笼子清洗设备和26个可操作区域 高压灭菌器。使用IRBF空间的请求由一个监督委员会进行评估，该委员会提出 给癌症研究所所长的建议，他有权在 大楼。每名调查员都要缴纳使用该设施的费用，以收回工作人员费用。这个 该设施支持24名调查人员的研究，并满负荷运行。约翰·诺顿博士，主任 实验动物资源司司长和IRBF业务主任，拥有 负责管理和监督动物护理项目。达雷尔·比格纳博士是 IRBF的协调员。CCIF配备了14名技术人员和一名共享资源经理，他们是 负责照顾8000个笼子里的老鼠，这些老鼠必须保持在栅栏下或 建筑设计提供的围堵条件。该设施由3名全职人员提供支持 机械师从机构资源中支付费用，以维护和确保机械系统在 生物危害控制指南。CCIF为体内异种生物和CT提供了支持空间 影像资源和无线标签共享资源。

The Cancer Institute Isolation Facility (CCIF) which houses the Immunoincompetent Rodent and Biocontainment Facility is the oldest shared resource in the Duke Comprehensive Cancer Institute. This facility provides Cancer Institute investigators with special isolated laboratories for work with hazardous biomolecules, certain recombinant DNA procedures, and for the maintenance of immunosuppressed and specific pathogen-free rodents or for other experiments that require biosafety level 2 and 3 containment needed to investigate cancer biology and treatment. The building has a total of 30,000 square feet which includes eight modules housing 3 lead lined rooms, 2 horsfall rooms, 24 animal holding rooms, 8 laboratories, support areas for mechanical equipment, cage washing equipment and 26 operational autoclaves. Request for use of the space in the IRBF is evaluated by an Oversight Committee which makes recommendations to the Director of the Cancer Institute who has the authority to assign space in the building. Each investigator is assessed a fee for the use of the facility to recover the cost of staffing. The facility supports the research of 24 investigators and operates at full capacity. Dr. John N. Norton, Director of the Division of Laboratory Animal Resources and the Director of Operations of the IRBF, has the responsibility of managing and overseeing the animal care program. Dr. Darell Bigner is the scientific Coordinator of the IRBF. The CCIF is staffed with 14 technicians and a shared resource manager who are responsible for providing care to the 8000 cages of rodents which must be maintained under barrier or containment conditions provided by the design ofthe building. The facility is supported by 3 full-time mechanics paid from institutional resources to maintain and ensure the mechanical systems operate within biohazard containment guidelines. The CCIF provides space to support the In Vivo Xenogen and CT Imaging Resource and Radiolabeling Shared Resource.