Centers for Cardiovascular Outcomes Research

描述（由申请人提供）：本建议书由位于伯明翰的亚拉巴马大学预防医学部的协作研究中心（CSC）和结局与有效性研究与教育中心（COERE）提出，作为我们设想的NHBLI心血管结局研究项目中心（CCORP）的研究协调单位（RCU）。虽然CCORP需要从典型协调中心的操作中获得很多东西，但它提出了挑战，因为它涵盖了相当广泛的 心血管疾病结局研究的主题和要进行的研究的性质在当时尚不清楚。 提案准备。这意味着一个成功的区域协调股必须在心血管疾病和成果研究方面拥有广泛的专业知识，必须拥有设施和人力资源，为计划活动提供高质量和及时但高度适应性的支持。此外，协调方案作为一个整体，特别是区域协调股利用协调方案内部以及更广泛的心血管疾病成果界的合作的能力，将在最大限度地发挥其影响方面发挥关键作用。拟议的公务员制度委员会区域协调股小组及其总体设施和人力资源非常适合这项任务。领导层，博士人，威廉姆斯和刘易斯有大约50人多年的CC经验，在众多的心血管疾病和成果的研究项目，其中一些侧重于心血管疾病的成果研究。由于刘易斯博士在该领域的领导地位，它还在现场中心和临床中心拥有约15年的大规模临床试验和观察性研究经验。此外，气候服务中心的总体资源和设施是在过去15年中专门为这类项目建立的，因此特别适合应对气候技术合作方案的挑战。我们的总体目标是与各中心、研究委员会和NHLBI工作人员密切合作，根据CCORP的发展需要提供RCU支持。我们的具体目标包括为研究管理提供卓越的基础设施;作为成果研究，成本效益，数据源，统计分析，质量保证计划和控制系统，数据管理和安全性的资源;以及开发用于评估整个计划的综合指标。

DESCRIPTION (provided by applicant): This proposal to serve as the Research Coordinating Unit (RCU) for what we envision as the NHBLI Centers for Cardiovascular Outcomes Research Program (CCORP) is from the Collaborative Studies Center (CSC) and the Center for Outcomes and Effectiveness Research and Education (COERE) of the University of Alabama at Birmingham Division of Preventive Medicine. While requiring much of what is available from the operations of a typical coordinating center, the CCORP presents challenges in that it covers the rather broad topic of CVD outcomes research and the nature of the research to be done is unknown at the time of proposal preparation. This means that a successful RCU must have broad expertise in CVD and outcomes research and must have the facility and personnel resources to provide high quality and timely but also highly adaptive support for Program activities. Also, the ability of the CCORP as a whole and of the RCU in particular to leverage collaborations within the CCORP as well as more broadly within the CVD outcomes community will play a critical part in maximizing its impact. The proposed CSC RCU team and its overall facility and personnel resources are unusually well suited for this task. The leadership, Drs. Person, Williams and Lewis has some 50 person years of CC experience over numerous CVD and outcomes research projects, several of which focused on CVD outcomes research. It also has some 15 additional years of experience with field center and clinical centers for large scale clinical trials and observational studies as a consequence of Dr. Lewis's leadership in this area. Further, the overall resources and facilities of the CSC have been created over the past 15 years specifically for projects such as this and thus is especially well suited for the CCORP challenges. Our general aim is to work closely with the centers, study committees, and NHLBI staff to provide RCU support as required for the CCORP to thrive. Our specific aims include providing an excellent infrastructure for study management; serving as a resource in outcomes research, cost effectiveness, data sources, statistical analyses, quality assurance plans and control systems, data management and security; and developing comprehensive metrics for evaluating the Program as a whole.