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Role of Innate and Adaptive Immune Systems in Drug-Induced Liver Disease

Role of Innate and Adaptive Immune Systems in Drug-Induced Liver Disease
先天性和适应性免疫系统在药物性肝病中的作用
批准号：
8558025
负责人：
Lance R Pohl
金额：
$69.53万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8558025
关键词：
AcidsAdjuvantAnimal ModelAnimalsAntibodiesAnticonvulsantsAntigen-Presenting CellsCategoriesCellsClinicalDisulfiramDrug toxicityEndothelial CellsErythromycinEthanolFemaleGoalsHalothaneHepaticHepatocyteHumanImmuneImmune responseImmune systemInjuryKupffer CellsLiverMediatingModelingMusMyelogenousPharmaceutical PreparationsPlayProcessProteinsReactionRegulatory T-LymphocyteReportingRoleSulfonamidesSuppressor-Effector T-LymphocytesT-LymphocyteTestingToxic effectadductanimal model developmentdrug induced liver diseaseimmunopathologypreventtroglitazone

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中文摘要
翻译
我们以前已经发现，调节性T细胞和骨髓来源的抑制细胞浸润到氟烷治疗后的雌性小鼠的肝脏，似乎有耐受性的活动，防止氟烷引起对肝脏的适应性免疫反应。 今年我们报道了其他几种潜在的耐受性细胞在氟烷治疗后进入肝脏。 结论：这些发现表明，多种致耐受性细胞在防止药物引起针对肝脏的适应性免疫反应中发挥作用。 阻断这些细胞的活性可能允许开发动物模型，用于测试新的对肝脏产生适应性免疫毒性的潜力。
英文摘要
We have previously found that regulatory T cells and myeloid-derived suppressor cells infiltrated into the liver of female mice following halothane treatment and appeared to have tolerogenic activity preventing halothane to cause an adaptive immune response against the liver. This year we report that several other potentially tolerogenic cells enter the liver after halothane treatment. Conclusion: These findings suggest that multiple tolerogenic cells play a role in preventing drugs from cause adaptive immune reactions against the liver. Blocking the activities of these cells may allow the development of animal models for testing the potential of new for causing adaptive immune toxicities against the liver.
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Mechanisms of Drug-Induced Liver Disease
Mechanisms Of Drug-induced Toxicities
Mechanisms of Drug-Induced Liver Disease
Role of Innate and Adaptive Immune Systems in Drug-Induced Liver Disease
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