Thomas L. Petty Conference: Mechanics and Mechanisms of Pulmonary Hypertension

描述（由申请人提供）：第55届Thomas L. Petty Aspen年度肺脏会议的主题是“肺动脉高压的力学和机制”。重点将放在肺血管疾病和肺血管-右心室轴领域的基础、转化和临床科学的整合上。肺动脉高压的临床影响将在确定疾病发病机制事件的同时进行探讨。在12个“最先进”的报告的基础上，专题会议将讨论遗传易感性和流行病学、肺血管干和祖细胞生物学、右心室衰竭和右心室-肺动脉耦合的作用、基因突变、表观遗传学、全身性炎症、新型靶向治疗和疾病修饰干预。这一重点与NHLBI最近致力于解决肺动脉高压和右心室衰竭/功能障碍的机制一致。会议总结将由医学教授、吉森大学医院内科主任Werner Seeger医学博士发表。Seeger博士担任肺中心主席，马克斯普朗克心肺研究所所长，是肺血管疾病领域的国际公认专家。会议的主要目标是：1)为基础和临床研究人员提供一个国际论坛，交流有关肺血管和右心室疾病的想法；2)鼓励和发展对知识快速发展领域的参与，通过引进和与知名专家合作，促进初级研究人员进入该领域；3)通过与国际公认的临床医生和研究人员的回顾和讨论，为参与者提供深入关注单一主题的机会；4)为肺部医学的进一步研究提供了动力。

DESCRIPTION (provided by applicant): The theme of the 55th Annual Thomas L. Petty Aspen Lung Conference is "Mechanics and Mechanisms of Pulmonary Hypertension". The emphasis will be on the integration of basic, translational and clinical sciences in the area of pulmonary vascular disease and pulmonary vascular-right ventricular axis. The clinical impact of pulmonary hypertension will be explored while identifying the mechanistic events in the disease's pathogenesis. Anchored by twelve "state-of-the-art" presentations, thematic sessions will address genetic susceptibility and epidemiology, pulmonary vascular stem and progenitor cell biology, role of the right ventricle failure and right ventricular-pulmonary artery coupling, genetic mutations, epigenetics, systemic inflammation, novel targeted therapies, and disease modifying interventions. This focus is in line with the recent effort by the NHLBI to address the mechanisms underlying both pulmonary hypertension and right ventricular failure/dysfunction. The Conference Summary will be presented by Werner Seeger, M.D., Professor of Medicine, Chief of the Department of Internal Medicine at the University of Giessen Hospital. Dr Seeger serves as chairman of the Lung Center, and Director of the Max Planck Institute for Heart and Lung Research and is an internationally recognized expert in the field of pulmonary vascular disease. The main objectives of the conference are to 1) provide an international forum for basic and clinical researchers to exchange ideas relating to pulmonary vascular and right ventricular disease; 2) encourage and develop participation in a field where knowledge is rapidly advancing, facilitating entry of junior investigators into the arena via introduction and collaboration with established experts; 3) provide an opportunity for participants to focus in depth on a single topic by review and discussion with internationally recognized clinicians and researchers; and 4) provide an impetus to further research in pulmonary medicine.