Evidence for Establishing Optimum Protein Intake in Older Adults

与最初提交的文件相比的更改 项目摘要 研究项目：来自小型临床研究的数据表明，目前的蛋白质推荐可能 突出显示 对老年人来说并不是最理想的，但来自基于人群的研究的证据很少。在.期间 在奖项的指导阶段，候选人建议为新出现的证据基础做出贡献 通过评估潜在的益处和利用流行病学数据建立最佳蛋白质摄入量 蛋白质摄入量过高与身体功能和肾功能的不良关联 在颁奖的独立阶段，比斯利博士将负责 在 妇女健康倡议。 对8000名妇女健康倡议参与者的食物频率调查问卷 80岁及以上老年人的扩展研究；3)评估500名女性子组的肾功能 使用肌酐和胱抑素C；4)测量蛋白质摄入量和肾脏变化之间的关系 使用短性能物理电池的功能和物理功能。 候选人和 环境：比斯利博士是由美国国家老龄研究所资助的NRSA研究员 集团化 健康研究所和弗雷德·哈钦森癌症研究中心的一名工作人员。Dr。 比斯利在北卡罗来纳大学教堂山分校接受公共健康营养培训 并在约翰·霍普金斯大学获得流行病学博士学位。职业生涯发展 该奖项提供了在老龄化和统计分析方面所需的额外培训，因此比斯利博士将 能够提供科学证据，帮助确定老年人的营养建议 以维持身体机能，减轻慢性病负担。

Changes from the original submission Project Summary Research Project: Data from small clinical studies suggest that current protein recommendations may highlighted not be optimal for older adults, but evidence from population-based studies is sparse. During the mentored phase of the award, the candidate proposes to contribute to the emerging evidence base for establishing optimal protein intake using epidemiologic data by evaluating potential benefits and adverse associations of higher protein intake with physical function and kidney function During the independent phase of the award, Dr. Beasley will 2) administer in the Women's Health Initiative. a food frequency questionnaire to a cohort of 8,000 participants of the Women's Health Initiative Extension Study aged 80 and over older adults; 3) assess renal function in a subset of 500 women using creatinine and cystatin C; 4) measure associations between protein intake and changes in renal function and physical function using the Short Performance Physical Battery. Candidate and Environment: Dr. Beasley is a NRSA fellow funded by the National Institute of Aging at the Group Health Research Institute and a staff scientist at the Fred Hutchinson Cancer Research Center. Dr. Beasley received training in public health nutrition at the University of North Carolina at Chapel Hill and earned her doctorate in epidemiology from Johns Hopkins University. The career development award provides the additional training needed in aging and statistical analysis, so Dr. Beasley will be able to contribute scientific evidence that would help define nutrient recommendations for older adults in order to maintain physical function and reduce the burden of chronic disease.