Evidence for Establishing Optimum Protein Intake in Older Adults

描述(由申请人提供)：与最初提交的项目摘要研究项目的变化：来自小型临床研究的数据表明，当前的蛋白质推荐可能不是老年人的最佳选择，但来自基于人群的研究的证据很少。在该奖项的指导阶段，候选人建议通过评估更高的蛋白质摄入量与身体功能和肾功能的潜在益处和不利关联，为利用流行病学数据建立最佳蛋白质摄入量的新出现的证据基础做出贡献。对8,000名年龄在80岁及以上的妇女健康倡议扩展研究参与者进行食物频率问卷调查；3)使用肌酐和胱抑素C评估500名妇女的肾功能；4)使用短性能物理电池测量蛋白质摄入量与肾功能和身体功能变化之间的关系。候选人和环境：比斯利博士是由国家老龄研究所在团体健康研究所资助的NRSA研究员，弗雷德·哈钦森癌症研究中心的专职科学家。比斯利博士在北卡罗来纳大学教堂山分校接受公共卫生营养学培训，并在约翰·霍普金斯大学获得流行病学博士学位。职业发展奖提供了老龄化和统计分析方面所需的额外培训，因此比斯利博士将能够提供科学证据，帮助确定老年人的营养建议，以维持身体机能，减轻慢性病的负担。 公共健康相关性：项目叙述公共健康相关性：评估较高蛋白质摄入量对长期健康结果的益处和风险将为饮食指南提供信息。这项研究将有助于产生科学证据，帮助确定老年人在保持身体功能和减少发病率方面的营养需求。词库术语：膳食评估；蛋白质；老年人；身体功能；肾功能

DESCRIPTION (provided by applicant): Changes from the original submission Project Summary Research Project: Data from small clinical studies suggest that current protein recommendations may highlighted not be optimal for older adults, but evidence from population-based studies is sparse. During the mentored phase of the award, the candidate proposes to contribute to the emerging evidence base for establishing optimal protein intake using epidemiologic data by evaluating potential benefits and adverse associations of higher protein intake with physical function and kidney function During the independent phase of the award, Dr. Beasley will 2) administer in the Women's Health Initiative. a food frequency questionnaire to a cohort of 8,000 participants of the Women's Health Initiative Extension Study aged 80 and over older adults; 3) assess renal function in a subset of 500 women using creatinine and cystatin C; 4) measure associations between protein intake and changes in renal function and physical function using the Short Performance Physical Battery. Candidate and Environment: Dr. Beasley is a NRSA fellow funded by the National Institute of Aging at the Group Health Research Institute and a staff scientist at the Fred Hutchinson Cancer Research Center. Dr. Beasley received training in public health nutrition at the University of North Carolina at Chapel Hill and earned her doctorate in epidemiology from Johns Hopkins University. The career development award provides the additional training needed in aging and statistical analysis, so Dr. Beasley will be able to contribute scientific evidence that would help define nutrient recommendations for older adults in order to maintain physical function and reduce the burden of chronic disease. PUBLIC HEALTH RELEVANCE: Project Narrative Public Health Relevance: Assessing the benefits and risks of higher protein intake on long-term health outcomes will inform dietary guidelines. This research will help to produce the scientific evidence that would help define the nutritional needs of older adults for preserving physical function and reducing morbidity. Thesaurus Terms: dietary assessment; protein; older adults; physical function; renal function