Evidence for Establishing Optimum Protein Intake in Older Adults

确定老年人最佳蛋白质摄入量的证据

• 批准号: 8183812
• 负责人: Jeannette Michele Beasley
• 金额: $ 10.53万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8183812
• 关键词: Elderly; Intake; Proteins

DESCRIPTION (provided by applicant): Changes from the original submission Project Summary Research Project: Data from small clinical studies suggest that current protein recommendations may highlighted not be optimal for older adults, but evidence from population-based studies is sparse. During the mentored phase of the award, the candidate proposes to contribute to the emerging evidence base for establishing optimal protein intake using epidemiologic data by evaluating potential benefits and adverse associations of higher protein intake with physical function and kidney function During the independent phase of the award, Dr. Beasley will 2) administer in the Women's Health Initiative. a food frequency questionnaire to a cohort of 8,000 participants of the Women's Health Initiative Extension Study aged 80 and over older adults; 3) assess renal function in a subset of 500 women using creatinine and cystatin C; 4) measure associations between protein intake and changes in renal function and physical function using the Short Performance Physical Battery. Candidate and Environment: Dr. Beasley is a NRSA fellow funded by the National Institute of Aging at the Group Health Research Institute and a staff scientist at the Fred Hutchinson Cancer Research Center. Dr. Beasley received training in public health nutrition at the University of North Carolina at Chapel Hill and earned her doctorate in epidemiology from Johns Hopkins University. The career development award provides the additional training needed in aging and statistical analysis, so Dr. Beasley will be able to contribute scientific evidence that would help define nutrient recommendations for older adults in order to maintain physical function and reduce the burden of chronic disease. PUBLIC HEALTH RELEVANCE: Project Narrative Public Health Relevance: Assessing the benefits and risks of higher protein intake on long-term health outcomes will inform dietary guidelines. This research will help to produce the scientific evidence that would help define the nutritional needs of older adults for preserving physical function and reducing morbidity. Thesaurus Terms: dietary assessment; protein; older adults; physical function; renal function

描述（由申请人提供）：与原始提交内容相比的变化项目摘要研究项目：小型临床研究的数据表明，当前的蛋白质建议可能不是老年人的最佳选择，但基于人群的研究证据很少。在该奖项的指导阶段，候选人建议通过评估较高蛋白质摄入量与身体功能和肾功能的潜在益处和不利关联，为使用流行病学数据建立最佳蛋白质摄入量的新兴证据基础做出贡献。在该奖项的独立阶段，比斯利博士将 2) 管理妇女健康倡议。对女性健康倡议推广研究的 8,000 名 80 岁及以上老年人的参与者进行了食物频率调查问卷； 3) 使用肌酐和胱抑素 C 评估 500 名女性的肾功能； 4) 使用短期性能物理电池测量蛋白质摄入量与肾功能和身体功能变化之间的关联。 候选人和环境：Beasley 博士是由国家老龄化研究所团体健康研究所资助的 NRSA 研究员，也是 Fred Hutchinson 癌症研究中心的科学家。比斯利博士在北卡罗来纳大学教堂山分校接受了公共卫生营养学培训，并在约翰霍普金斯大学获得了流行病学博士学位。职业发展奖提供了老龄化和统计分析所需的额外培训，因此比斯利博士将能够提供科学证据，帮助确定老年人的营养建议，以维持身体机能并减轻慢性疾病的负担。 公共卫生相关性：项目叙述公共卫生相关性：评估较高蛋白质摄入量对长期健康结果的益处和风险将为饮食指南提供信息。这项研究将有助于提供科学证据，帮助确定老年人保持身体机能和降低发病率的营养需求。同义词库术语：饮食评估；蛋白质;老年人；身体机能；肾功能