Reduce Risk of Diabetes:Healthy Lifestyle for Chinese Immigrants

描述（由申请人提供）：本R34申请的目标是基于糖尿病预防计划的干预原则，为有糖尿病风险的中国移民创建并形成评估促进健康生活方式的干预措施。干预的可接受性和可行性将在一项双臂随机试验（n=60）中进行评估，该试验将比较生活方式干预（n=30）和最小控制干预（n=30）的效果。6个月末和12个月时的R34评估将检查体重和生物标志物的变化，包括空腹血糖和胰岛素、HbA1c、脂质谱（总胆固醇、HDL和LDL胆固醇、甘油三酯）和血压。衡量生活方式改变的方法包括饮食摄入和身体活动。这项研究还将评估心理测量的变化。试点研究将使用RE-AIM评估框架来关注：Reach -有多少符合条件的参与者实际参加了研究？功效-干预如何影响参与者的体重和其他指标？采纳：参与者对干预的接受程度如何？实施情况-有多少干预活动是按计划进行的？维持-有多少干预效果是可持续的？干预的长期效果将在随后的R18临床试验中进行评估。

DESCRIPTION (provided by applicant): The goal of this R34 application is to create and formative evaluate an intervention that promotes healthful lifestyle for Chinese immigrants at risk for developing diabetes based on the principles of Diabetes Prevention Program intervention. The acceptability and feasibility of the intervention will be assessed in a two-arm pilot randomized trial (n=60) that will compare the effects of a lifestyle intervention (n=30) to a minimal control intervention (n=30). The R34 evaluation at the end of 6 months and at 12 months will examine changes in weight and biomarkers including fasting blood glucose and insulin, HbA1c, lipid profile (total, HDL and LDL cholesterol, and triglycerides), and blood pressure. Measures of lifestyle changes will include dietary intake and physical activity. The study will also assess change in psychological measures. The pilot study will use the RE-AIM evaluation framework to focus on: Reach - How many of the eligible participants actually enrolled in the study? Efficacy/Effectiveness -How did the intervention affect participant's weight and other measures? Adoption: How acceptable were the interventions to the participants? Implementation - How many of the intervention activities were provided as planned? Maintenance - How much of the intervention effect is sustainable? The longer term effects of the intervention will be evaluated in a subsequent R18 clinical trial. PUBLIC HEALTH RELEVANCE: Lifestyle change can reduce the risk of developing diabetes. This project will tailor the successful Diabetes Prevention Program lifestyle intervention to focus on the needs of high risk immigrants from China. The effects of the intervention will be evaluated in a pilot study assessing lifestyle and weight changes. The evaluation of the intervention will be used to plan a larger study to examine health outcomes.