ASSAY CORE

核心A测量项目1和2中研究患者的血清、血清超滤液（UF）、血浆和尿结石风险化学物质，并计算尿液过饱和度（SS）。这些测量用于实现所有三个项目的目标和整个项目中的六个项目目标。对于项目1，还将通过核心A测量血浆GLP-1、肾素以及血浆和尿液cAMP。 处理并运输血液和尿液样本，用于在核心B中进行锂含量测定，并用于测量血浆胰高血糖素、甲状旁腺激素（PTH）和1，25维生素D（由LabCorp进行）。 将样品等分试样储存在-80 ° C下以备将来使用。所有项目的核心A的所有实验室数据都整合到一个数据库中，每天备份，以确保安全性和易于分析。最终，来自其他项目和核心的数据（例如组织学、活检、结石分析等）将被整合到我们的 数据库，以便可以与血清和尿液数据一起进行沿着分析。

Core A measures serum, serum ultrafiltrate (UF), plasma and urine stone risk chemistries and calculates urine supersaturations (SS) for patients studied in Projects 1 and 2. These measurements are used for fulfillment of aims within all three projects and six program aims carried out within the overall program project. Plasma GLP-1, renin, and plasma and urine cAMP will also be measured by Core A for Project 1. Blood and urine samples are processed and shipped for assay of lithium done in Core B and for measurement of plasma glucagon, parathyroid hormone (PTH) and 1,25 vitamin D (performed by LabCorp). Sample aliquots are stored at -80¿C for future use. All laboratory data from Core A for all projects are consolidated into a single database with daily backup for security and ease of analysis. Ultimately, data from the other projects and cores (e.g. histology, biopsy, stone analysis etc.) will be consolidated into our database so that it can be analyzed along with serum and urine data.