Genetic Susceptibility And The Environment In Cancer Risk

摘要： 该实验室最近的工作重点是前列腺癌的侵袭性。全基因组关联研究已经确定了一些常见的SNP与欧洲血统人群前列腺癌风险相关，尽管这些SNP只解释了可遗传成分的一小部分。对这些SNP的复制和精细定位研究主要集中在欧洲人身上。尽管非裔美国人患前列腺癌的风险较高，但他们接受评估的频率较低。我们建立了一个由1,536个SNPs组成的小组，其中34个SNPs来自欧洲的GWAS，38个SNPs位于侧翼。使用这些SNPs，我们对来自北卡罗来纳州-洛杉矶前列腺癌项目(PCAP)的1060名非洲裔美国人和1087名欧洲裔美国人前列腺癌患者的血液样本进行了基因分型。我们发现4个Gwas复制SNPs和7个侧翼SNPs与前列腺癌侵袭性相关。

Summary: Recent work in the laboratory has focused on prostate cancer aggressiveness. Genome-wide association studies (GWAS) have identified a number of common SNPs that are associated with prostate cancer risk in populations of European descent, although these SNPs explain only a small fraction of the heritable component. Replication and fine mapping studies of these SNPs have focused largely on Europeans. African Americans have been evaluated less frequently despite their higher risk of prostate cancer. We established a panel of 1,536 SNPs including 34 SNPs from European-based GWAS and 38 flanking SNPs. Using these SNPs we genotyped blood samples from 1,060 African American and 1087 European American men with prostate cancer from the NC-LA Prostate Cancer Project (PCaP). We found four GWAS replication SNPs and 7 flanking SNPs associated with prostate cancer aggressiveness.