Administrative Core

根据医学研究所(IOM)关于缓解美国疼痛的报告(2011年6月)，慢性疼痛是一种公共卫生流行病，影响着1.16亿美国人，每年造成超过6000亿美元的医疗费用和工作效率损失。更多的美国人遭受痛苦，比那些患有心脏病、糖尿病和癌症的人加起来还要多。尽管最近在治疗方面取得了进展，但大多数患者并没有获得足够的疼痛缓解。几十年的疼痛研究几乎没有产生可用药的靶点，因此需要新的方法，不仅考虑到疼痛，而且考虑到共病的疼痛条件和个体差异(例如，遗传和基因组变异)。这一核心和中心应用的概念基础承认，伤害性感受(伤害性刺激的神经处理)和疼痛(不愉快的情绪体验)是多因素的，共病，如抑郁、焦虑、压力和恐惧，以及个体易感性(如遗传学和基因组学)显著影响这些过程(Maixner等人，2011年)。 马里兰大学疼痛基因组学研究中心(以下简称“中心”)致力于推动慢性疼痛研究的科学化，在基础研究、翻译研究和临床研究中结合并存疾病的测量和基因组学评估。为了实现我们的目标，我们将加强我们的校园研究基础设施，以增加纳入这些措施的跨学科慢性疼痛研究的数量和质量。在我们目前的NINR P30癌症疼痛中心，许多教员在癌症疼痛研究方面进行了合作。该研究项目被认为是一个正在开发的项目，现在已经正式进入Greenebaum癌症中心，并正在蓬勃发展。在国际移民组织最近发布了关于慢性疼痛的报告后，我们认识到有必要扩大校园内的疼痛研究，以便更广泛地关注慢性疼痛状况。在仔细考虑了重点之后，我们选择了在基因组学领域进行扩展，同时也解决了风险表型(例如，抑郁、恐惧、焦虑、压力)。这将把在行为表型和基因组学方面具有专业知识的新合作者带入疼痛研究领域。中心资金将使我们能够正式、增强和制定计划，以维持这个新的中心在校园内的地位。我们通过中心活动对慢性疼痛研究的承诺将通过以下五个管理核心(AC)目标来促进： 目标1.监督和协调中心的行政职能，包括各核心机构和试点个人投资机构使用资金的情况，并确保适当使用资金。 目标2.优化和提高我们校园和整个马里兰大学系统(USM)的核心资源利用率。 目的3.建立、维护和发展中心网站，作为马里兰大学巴尔的摩分校慢性疼痛研究的门户，并作为中心活动向更广泛的疼痛、科学和患者社区传播的机制。 目标4.规划并积极争取内部、外部和基金会资金，以在P30资助期内和之后维持和扩大中心的研究活动。 目的5.确保中心的有效性，以实现其规定的成果，包括成功完成试点研究，为共享资源创建可持续的基础设施以促进专业间疼痛基因组研究，以及在校园、区域、国家和国际各级传播中心的活动。 这些目标与该中心的使命相关，实际上也与建设能力和基础设施相关，以支持、发展和维持马里兰大学巴尔的摩分校和护理学院的跨学科疼痛研究。

According to the Institute of Medicine (IOM) report on Relieving Pain in America (June, 2011), chronic pain is a public health epidemic affecting more than 116 million Americans and costing more than $600 billion per year in healthcare expenses and lost work productivity. More Americans suffer from pain than those afflicted with heart disease, diabetes and cancer combined. Despite recent advances in treatment, most patients do not obtain adequate pain relief. Decades of pain research have produced few druggable targets, thus new approaches that take into account not just pain, but also comorbid pain conditions and individual differences (e.g., genetic and genomic variation) are needed. The conceptual basis for this core and center application acknowledges that nociception (neural processing of noxious stimulation) and pain (unpleasant emotional experience) are multifactorial and that co-morbidities, for example depression, anxiety, stress, and fear, and individual susceptibility (e.g., genetics and genomics) significantly influence these processes (Maixner et al., 2011). The University of Maryland Center for the Genomics of Pain (hereafter referred to as the "Center") is dedicated to advancing the science of chronic pain research that incorporates the measurement of comorbid conditions and evaluation of genomics in basic, translational and clinical studies. To achieve our objectives, we will enhance our campus research infrastructure to increase the quantity and quality of interdisciplinary chronic pain studies that incorporate these measures. A number of faculty collaborate on cancer pain research in our current NINR P30 Center for Cancer Pain. This research program, recognized as a Developing Program, has now moved formally into the Greenebaum Cancer Center and is thriving. Subsequent to the release of the recent IOM report on chronic pain, we recognized the need to expand pain research on campus to more broadly focus on chronic pain conditions. After carefully considering the focus, we chose to expand in the area of genomics and also, address risk phenotypes (e.g., depression, fear, anxiety, stress). This will bring new collaborators with expertise in behavioral phenotyping and genomics into the pain research field. Center funding will enable us to formalize, enhance, and enact plans to sustain this new Center on campus. Our commitment to chronic pain research through Center activities will be facilitated through the following five Administrative Core (AC) Aims: Aim 1. Provide oversight and coordination of administrative functions of the Center, including utilization of funds by the Cores and Pilot PIs, and ensure that funds are expended appropriately. Aim 2. Optimize and enhance Core resource utilization at our campus and across the University of Maryland System (USM). Aim 3. Establish, maintain and grow the Center website as a portal for chronic pain research on the University of Maryland Baltimore campus and as a mechanism for dissemination of Center activities to the broader pain, science and patient communities. Aim 4. Plan for and actively pursue intramural, extramural and foundation funding to sustain and expand the Center research activities, during and beyond the P30 funding period. Aim 5. Ensure the effectiveness of the Center to achieve its stated outcomes, including successful completion of pilot studies, creation of sustainable infrastructure for shared resources to facilitate interprofessional pain genomics research, and the dissemination of Center activities at the campus, regional, national and international levels. These aims are relevant to the mission of the Center, and indeed, to building the capacity and infrastructure to support, grow, and sustain interdisciplinary pain research on the University of Maryland Baltimore campus and in the School of Nursing.