TRIAD Administrative Core

为了应对新出现的传染病和转基因生物武器/生物恐怖制剂的双重威胁， 迫切需要更有效的疫苗研发系统。三合一，或翻译 基于生物技术的免疫学研究和加速[疫苗]开发计划 在罗德岛大学的项目中，已经率先开发和应用了 “基因到疫苗”在硅胶、体外和体内的疫苗设计方案解决了这一需求，并选择了 A类病原菌F·图拉氏杆菌，B类病原菌伯克霍尔德氏菌和伯克霍尔德氏菌， 和新出现的传染病(丙型肝炎病毒、幽门螺杆菌、壁虱传播的疾病)作为我们提案的重点。 三合会将有三个主要目标，由中央行政核心管理： 1.创建易于访问的疫苗开发免疫信息学工具的核心集合(Triad工具包 核心)和用于验证其应用结果的技术(CMI核心)。 2.说明四个疫苗开发方案的工具和技术的使用：多细胞内方案 病原体疫苗(图拉热症和假鼻疽杆菌、马来杆菌)、幽门螺杆菌和丙型肝炎，以及 壁虱传播的疾病， 3.通过试点赠款方案倡导使用这些工具--培训研究界成员以 通过座谈会、讲习班和试点赠款利用这些工具。 三合会的管理核心位于罗德岛大学的生物技术项目。这个 生物技术计划致力于为生物技术实践培训提供最佳环境。 例如疫苗，从概念到生产。这项提议与生物技术的目标是协同的 程序。三合会计划与由同一机构管理的RL EPSCoR完美结合 一组专家管理员。该项目与RFA的目标一致，带来了 一个综合的合作者小组，负责疫苗设计和新疫苗研究人员的培训。

To meet the dual threats of emerging infectious diseases and engineered biowarfare/bioterror agents, there is a pressing need for more efficient systems for vaccine development. TRIAD, or the Translational Immunology Research and Accelerated [Vaccine] Development program, based in the Biotechnology Program at the University of Rhode Island, has pioneered the development and application of an integrated "gene to vaccine" in silico, in vitro and in vivo vaccine design program to address this need, and has selected Category A pathogens F. tularensis, Category B agents Burkholderia pseudomallei and Burkholderia mallei, and emerging infectious diseases (HCV, H. pylori, tick borne diseases) as the focal point of our proposal. TRIAD will have three main objectives that will be managed by the central Administrative Core: 1. Create an easily accessed core collection of vaccine-development immunoinformatics tools (Triad Toolkit Core) and techniques (CMI core) for validating the results of their application. 2. Illustrate the use of the tools and techniques for four vaccine development programs: Multi-intracellular Pathogen Vaccine (Tularemia and B. pseudomallei, B. mallei), Helicobacter Pylori, and Hepatitis C, and Tick-borne diseases, 3. Advocate use of the tools through a pilot grant program - training members of the research community to exploit these tools, through symposia, workshops and pilot grants. TRIAD'S administrative core is located in the Biotechnology Program at the University of Rhode Island. The Biotech program is committed to providing the optimal environment for hands-on training in biotechnologies such as vaccines, from concept to manufacture. This proposal is synergistic with the aims of the Biotech program. The TRIAD program integrates perfectly with the Rl EPSCoR, which is administered by the same group of expert administrators. The project is consistent with the goals of the RFA, bringing the expertise of an integrated group of collaborators to bear on vaccine design and the training of new vaccine researchers.