Improving oocyte mitochondrial DNA copy number to enhance female reproductive capacity.

线粒体DNA拷贝太少的卵子要么不能受精，要么在早期发育过程中停止发育。通过为卵子补充线粒体DNA，我们已经能够提高胚胎质量和基因表达谱。通过培育来自给予线粒体补充剂的卵子的后代，我们将确定它们及其后代是否符合正常的发育里程碑，适当调节线粒体DNA的传递，并且是健康和可育的。

Eggs with too few copies of mitochondrial DNA either fail to fertilise or arrest during early development. By supplementing eggs with mitochondrial DNA, we have been able to enhance embryo quality and gene expression profiles. By breeding the offspring derived from eggs given mitochondrial supplementation, we will determine if they and their progeny meet normal developmental milestones, regulate the transmission of mitochondrial DNA appropriately, and are healthy and fertile.