Implementation Pilot 2

Meharry医学院（MMC）和Vanderbilt-Ingram癌症中心（VICC）建议开发一个以癌症生存研究和癌症生存健康差异为中心的新的创新计划。这是一个可持续和互利的计划，大大提高了目前的Meharry-Vanderbilt癌症合作伙伴关系（MVCP）资助的U 54，并有效地利用已经建立的资源。目前，美国有超过1100万人患有癌症，其中非洲裔美国人的死亡率高于其他种族/族裔群体，原因仅部分了解。对于癌症幸存者来说，癌症治疗的影响，生活方式行为和环境暴露也可能导致长期发病和过早死亡。然而，令人惊讶的是，很少有研究已经进行了“生存”，以评估长期的结果，特别是在成年癌症幸存者，特别是少数幸存者人群的基线健康差异存在。因此，需要描述性和分析性流行病学队列研究来估计不良生理和心理社会长期结果的发生率，并评估其决定因素，以告知预防干预措施的最佳实践的发展。该提案旨在规划、优先考虑和实施一系列合作试点项目，采用混合方法，具体目标如下：1）将癌症生存研究举措作为MVCP的优先事项，并将该研究和临床护理领域纳入现有的伙伴关系基础设施; 2）促进MMC、VICC和合作的少数民族机构田纳西州立大学教师之间的互动和合作; 3）促进对癌症生存率健康差异的决定因素的研究，包括生物学，社会经济，与得不到充分服务的人群生存率低相关的人口统计学和健康相关风险因素（包括有色人种、社会经济困难人群）; 4）确定癌症治疗后不良长期健康相关结局的发生率、患病率、范围和严重程度，并制定干预措施以预防或改善此类结局。这种扩大的合作伙伴关系和研究计划的好处包括MMC和VICC：1）教师发展和招聘，增加学员和初级教师对这一研究领域的接触; 2）增加试点项目和最终竞争性的校外资金，现在将包括沿着整个癌症控制连续体的研究; 3）扩大MVCP资助的U 54和VICC支持赠款，以包括癌症生存研究; 4）扩大癌症健康差异研究，以包括长期生存质量和数量差异的研究; 5）促进少数群体参与癌症生存差异研究，无论是研究者还是受试者。

DESCRIPTION (provided by applicant): The Meharry Medical College (MMC) and the Vanderbilt-lngram Cancer Center (VICC) propose to develop a new and innovative program centered on Cancer Survivorship Research and Cancer Survivorship Health Disparities. This is designed to be a sustainable and mutually beneficial program that significantly enhances the current Meharry-Vanderbilt Cancer Partnership (MVCP) funded U54, and efficiently utilizes already established resources. There are now over 11 million people in the United States living with a history of cancer with African Americans experiencing higher rates of mortality than do other racial/ethnic groups for reasons that are only partly understood. For cancer survivors, effects of the cancer treatment, lifestyle behaviors and environmental exposures can also lead to long-term morbidity and premature mortality. Yet, surprisingly little research has been conducted in "survivorship" to assess long term outcomes especially among adult cancer survivors, and in particular, minority survivor populations where baseline health disparities exist. Therefore, descriptive and analytic epidemiologic cohort studies are required to estimate the incidence of adverse physiologic and psychosocial long-term outcomes and evaluate their determinants to inform the development of best practices for preventive interventions. This proposal is designed to plan, prioritize and implement a series of collaborative pilot projects, using mixed methodologies with the following specific objectives: 1) To establish Cancer Survivorship research initiatives as a priority for the MVCP and integrate this area of research and clinical care into the existing partnership infrastructure; 2) To stimulate interactions and collaborations among faculty at MMC, VICC and a collaborating minority institution, Tennessee State University; 3) To stimulate research into the determinants of health disparities in cancer survivorship, including the biologic, socioeconomic, demographic and health-related risk factors associated with inferior survival of underserved populations (including populations of color, socio-economically challenged); and 4) To identify the incidence, prevalence, spectrum, and severity of adverse long-term health-related outcomes following cancer treatment and develop interventions to prevent or ameliorate such outcomes. The benefits of such an expanded partnership and program of research include for both MMC and VICC: 1) faculty development and recruitment with increased exposure to this line of research for trainees and junior faculty; 2) increases in pilot projects and ultimately competitive extramural funding that will now include research along the entire cancer control continuum; 3) expansion of the MVCP funded U54 and VICC support grant to include cancer survivorship research; 4) expansion of cancer health disparities research to include study of disparities in the quality and quantity of long-term survivorship; 5) facilitation of increased minority participation in cancer survivorship disparities research, with respect to both investigators and subjects.