Molecular Genetics of the Gonococcus

描述(申请人提供)：淋病奈瑟氏菌(GC)是一种性传播的传染病，是淋病的唯一病原体。作为一种严格的人类病原体，这种细菌已经进化出复杂的机制，以促进在受影响的人群中的定居和生长及其传播。淋病的中心是大量白细胞涌入，在有症状的GC感染期间，男性和女性都会发生这种情况。这种“化脓性渗出物”主要由人类多形核淋巴细胞(PMN)和相关的活性GC组成。GC与PMN之间的相互作用是其发病机制的重要组成部分。这一竞争性更新将继续探索我们已确定的对GC和PMN相互作用重要的新因子所使用的分子机制，揭示GC在PMN内和PMN之间生存的新机制，并确定GC如何调控PMN的凋亡途径。

DESCRIPTION (provided by applicant): Neisseria gonorrhoeae (Gc) is a sexually transmitted infectious agent that is the only causative agent of the disease gonorrhea. As a strict human pathogen, this bacterium has evolved sophisticated mechanisms to facilitate colonization and growth within affected human populations and its spread. Central to the disease gonorrhea is the massive influx of white cells that occurs in both males and females during symptomatic Gc infection. This "purulent exudate" consists predominately of human polymorphonuclear lymphocytes (PMNs) with associated viable Gc. The interplay between Gc and the PMN is an essential part of pathogenesis. This competitive renewal will continue to explore the molecular mechanisms used by novel factors we have identified that are important for the interaction of Gc and PMNs, to uncover new mechanisms important for Gc survival within and among PMNs, and to determine how Gc modulates the apoptotic pathways of PMNs.