Core 1 - Nanomaterials Synthesis, Fabrication, and Characterization

核心的功能 这一核心建立在华盛顿大学(UW)纳米技术优势的基础上，华盛顿大学是西海岸最古老的国家支持的高等教育机构之一，也是世界上最杰出的研究型大学之一。威斯康星大学纳米技术中心(CNT)由弗朗索瓦·巴内克斯教授领导，成立于1997年，拥有来自化学系的75多名教职员工， 物理学、生物工程(例如高教授)、化学工程(如Baneyx教授)、电气工程、材料科学与工程、生物化学、基因组科学、生理学与生物物理学和微生物学。它的纳米技术博士项目是通过美国国家科学基金会 综合研究生教育与研究培训奖(NSF-IGERT)是全国首个此类奖项；该计划为研究生提供优秀的纳米科学和技术跨学科教育经验，并强调职业道路发展。CNT也是纳米技术用户设施(NTUF)的所在地，该设施为太平洋西北地区的纳米技术社区提供先进的表征和纳米制造设备。2004年，NTUF将其作用扩大到国家一级，成为国家纳米技术基础设施网络(NNIN)的14个节点之一，NNIN是由NSF赞助的由13所大学组成的网络，其使命是为当前和未来纳米科学和纳米技术的研究和教育需求建立基础设施。 NTUF拥有尖端的仪器，这将是表征量子点(Qdots)的关键 下面将进行讨论。成像工具包括徕卡倒置荧光显微镜、雷尼绍Invia共焦显微镜 拉曼显微镜、具有电子束光刻能力的FEI场发射扫描电子显微镜、Vecco纳米显微镜 具有扫描隧道显微镜和液体模力距测量的扫描探针显微镜 功能，蔡司LSM510激光扫描共聚焦显微镜与原子力显微镜接口， 一台Woollam成像椭偏仪，以及最近收购的Tecnai 200千伏扫描透射式电子 具有层析成像能力的显微镜(S/透射电子显微镜)。制造工具包括软光刻、扫描电子显微镜中的Nabity电子束光刻系统、牛津蛋白石原子层沉积系统和海德堡无掩模图形写入器。NTUF还利用教员的研究和专业知识进行内部纳米技术工具的开发。此外。Baneyx教授、高教授和Yost教授在他们自己的实验室中也拥有最先进的仪器，用于纳米颗粒的制造、提纯和表征(见研究人员设备清单)。 在这一框架内，拟议的核心有以下具体职能： (1)为U19项目制备足够数量的表征良好和纯化的纳米颗粒； (2)气-液界面气溶胶生成及纳米粒子载体系统的构建 培养(项目1)和老鼠(项目2)到Qdots。

Functions of the Core This Core builds on the nanotechnology strengths at the University of Washington (UW), one of the oldest state-supported institutions of higher education on the west coast, and one of the preeminent research universities in the worid. The UW Center for Nanotechnology (CNT), directed by Professor Francois Baneyx, was established in 1997, and has more than seventy-five faculty members from the Departments of Chemistry, Physics, Bioengineering (e.g.. Prof. Gao), Chemical Engineering {e.g., Prof. Baneyx), Electrical Engineering, Materials Science and Engineering, Biochemistry, Genome Sciences, Physiology and Biophysics, and Microbiology. Its Ph.D. Program in Nanotechnology established through a National Science Foundation's Integrative Graduate Education and Research Traineeship (NSF-IGERT) award was the first of its kind in the nation; the program provides graduate students with excellent interdisciplinary education experiences in nanoscale science and technology and emphasizes career path development. CNT is also home to the NanoTech User Facility (NTUF), which provides the Pacific Northwest nanotechnology community with access to advanced characterization and nanofabrication equipment. In 2004, NTUF expanded its role to the national level by becoming one of 14 nodes in the National Nanotechnology Infrastructure Network (NNIN), an NSF sponsored network of 13 universities, whose mission is to establish the infrastructure for current and future research and education needs in nanoscience and nanotechnology. NTUF houses leading-edge instruments, that will be critical for the characterization of quantum dots (Qdots) discussed below. Imaging tools include a Leica inverted fluorescence microscope, a Renishaw inVia Confocal Raman Microscope, an FEI field emission SEM with electron beam lithography capability, a Vecco Nanoscope scanning probe microscope with scanning tunneling microscopy and liquid mode force-distance measurement capabilities, a Zeiss LSM510 laser scanning confocal microscope interfaced with an atomic force microscope, a Woollam imaging ellipsometer, and a recently acquired Tecnai 200 kV scanning transmission electron microscope (S/TEM) with tomography capability. Fabrication tools include soft lithography, a Nabity e-Beam lithography system in the SEM, an Oxford OpAL atomic layer deposition system and a Heidelberg maskless pattern writer. NTUF also performs in-house nanotechnology tool development by drawing on faculty research and expertise. In addition. Prof. Baneyx, Gao, and Yost also have state-of-the-art instruments in their own laboratories for nanoparticle fabrication, purification, and characterization (see investigator equipment lists). Within this framework, the proposed Core has the following specific functions: (1) Preparation of well-characterized and purified nanoparticles in sufficient quantities for the U19 projects; (2) Construction of an aerosol generation and nanoparticle carrier system for exposing air-liquid interface cultures (Project 1) and mice (Project 2) to Qdots.