Oogonial Stem Cell Characterization in POI and NHP

在这个令人兴奋的新兴领域，在过去的一年里，我们投入了大量时间来建立人类和动物方案以及基础科学技术，以便在我们的实验室开始这一新的研究路线。 为了检测可能的干细胞的潜力，在过去的一年里，我们在实验室建立了一个非人类灵长类卵细胞干细胞移植模型。 在人类中，我们的目标是在原发性卵巢功能不全/卵巢早衰、卵巢储备减少和医源性卵巢衰竭的疾病模型中研究这些细胞。在过去的一年里，我们已经开始招生，并正在进行实验研究这些细胞。

In this exciting, burgeoning field, over the past year we have invested substantial time in establishing human and animal protocols as well as basic science techniques to begin this new line of investigation in our laboratory. To examine the potential of putative stem cells, over the past year we have established a non-human primate oogonial stem cell transplant model in our lab. In humans, our aim is to study these cells in a disease model of primary ovarian insufficiency/ premature ovarian failure, diminished ovarian reserve and iatrogenically induced ovarian failure. Over the past year we have begun enrollment and are studying these cells in ongoing experiments.