Feasibility Of Community Based Tampon Self-Sampling To Prevent Cervical Cancer

描述（由申请人提供）：医疗服务不足的妇女通常面临包括宫颈癌在内的许多健康问题的更高风险。通常可以通过利用社区内的资源找到解决方案。已经形成了一个学术社区伙伴关系，以开发一种新的宫颈癌筛查方法。高危类型的人乳头瘤病毒（HPV）， 16,18和其他，在病因上与宫颈癌有关。HPV可以从阴道自拭、尿液检测或插入卫生棉条获得的样本中检测到。这些方法可以由妇女在社区或家中进行，这对没有去妇科医生那里接受推荐检测的妇女群体很有用。本研究将比较以家庭为基础的宫颈癌自我抽样筛查与以社区为基础的传统巴氏试验的有效性。考虑到家庭使用的便捷性，假设基于家庭的卫生棉条检测HPV DNA将等于或优于每年的巴氏涂片检测。为了使这种家庭抽样有效，它必须：(1)至少与目前妇科医生的转诊率一样多；(2)为妇女所接受的预防宫颈癌的手段；（三）能够在家演奏的；(4)能够识别那些有患宫颈癌风险的妇女。该项目的具体目的是：比较家庭抽样卫生棉条HPV检测的依从性与临床巴氏试验的依从性；评估高危人群对家庭使用卫生棉条进行HPV检测的接受程度，并与传统的临床应用巴氏涂片检测进行比较；评估高风险人群正确遵循家用卫生棉条取样进行HPV检测的能力；并评估家用卫生棉条HPV检测结果的准确性。为了实现这些目标，一组妇女将被要求在家中进行卫生棉条取样，并通过邮件返回。另一组将进行传统的巴氏试验进行比较。我们亦会进行满意度调查。

DESCRIPTION (provided by applicant): Medically underserved women are generally at higher risk for many health problems including cervical cancer. Solutions can often be found by utilizing resources within the community. An academic-community partnership has been formed to develop a novel approach to screening for cervical cancer. High risk types of human papillomavirus (HPV), 16, 18 and others, are etiologically linked to cervical cancer. HPV can be detected from samples obtained from self-swabbing of the vagina, urine testing, or insertion of tampons. These methods could be performed in the community or at home by women, which is useful for the group of women not visiting the gynecologist to receive recommended testing. This study will compare the effectiveness of home-based self sampling screening for cervical cancer with conventional Pap testing in a community-based setting. Given the ease of home use, it is hypothesized that home-based tampon testing for HPV DNA will be equal or superior to the annual Pap testing. For such home sampling to be effective, it must be: (1) used at least as much as current referral rates to the gynecologist; (2) acceptable to the woman as a means to prevent cervical cancer; (3) able to be performed at home; and (4) able to identify those women at risk for developing cervical cancer. The specific aims of this project are to: compare compliance with a home-sampling tampon HPV test to compliance with clinic Pap testing; assess a high risk population's acceptance of home use of a tampon for HPV testing in general and compared to traditional clinically administered Pap testing; assess a high risk population's ability to correctly follow instructions for home tampon sampling for HPV testing; and assess the accuracy of the home administered tampon HPV results. In order to achieve these aims, a group of women will be asked to administer the tampon sampling at home and return via mail. Another group will have conventional Pap testing for comparison. Surveys of satisfaction will also be conducted.